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dc.contributor.authorSousa, Luciana Pereira dept_BR
dc.contributor.authorGomes, Flávia Lima Ribeiropt_BR
dc.contributor.authorAlmeida, Roberto Farina dept_BR
dc.contributor.authorSouza, Tadeu Mello ept_BR
dc.contributor.authorWerneck, Guilherme Loureiropt_BR
dc.contributor.authorSouza, Diogo Onofre Gomes dept_BR
dc.contributor.authorRibeiro, Cláudio Tadeu Danielpt_BR
dc.date.accessioned2022-12-08T05:03:46Zpt_BR
dc.date.issued2021pt_BR
dc.identifier.issn2045-2322pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/252556pt_BR
dc.description.abstractThe immune system plays a role in the maintenance of healthy neurocognitive function. Different patterns of immune response triggered by distinct stimuli may affect nervous functions through regulatory or deregulatory signals, depending on the properties of the exogenous immunogens. Here, we investigate the effect of immune stimulation on cognitive-behavioural parameters in healthy mice and its impact on cognitive sequelae resulting from non-severe experimental malaria. We show that immune modulation induced by a specific combination of immune stimuli that induce a type 2 immune response can enhance long-term recognition memory in healthy adult mice subjected to novel object recognition task (NORT) and reverse a lack of recognition ability in NORT and anxiety-like behaviour in a light/dark task that result from a single episode of mild Plasmodium berghei ANKA malaria. Our findings suggest a potential use of immunogens for boosting and recovering recognition memory that may be impaired by chronic and infectious diseases and by the effects of ageing.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofScientific reports. London. Vol. 11 (2021), 14857, 11 p.pt_BR
dc.rightsOpen Accessen
dc.subjectDisfunção cognitivapt_BR
dc.subjectMaláriapt_BR
dc.subjectSistema imunitáriopt_BR
dc.subjectMemóriapt_BR
dc.titleImmune system challenge improves recognition memory and reverses malaria-induced cognitive impairment in micept_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001153538pt_BR
dc.type.originEstrangeiropt_BR


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