Mostrar registro simples

dc.contributor.authorBrondani, Rosanept_BR
dc.contributor.authorAlmeida, Andrea Garcia dept_BR
dc.contributor.authorCherubini, Pedro Abrahimpt_BR
dc.contributor.authorSecchi, Thaís Leitept_BR
dc.contributor.authorOliveira, Marina Amaral dept_BR
dc.contributor.authorMartins, Sheila Cristina Ouriquespt_BR
dc.contributor.authorBianchin, Marino Muxfeldtpt_BR
dc.date.accessioned2022-10-26T04:46:40Zpt_BR
dc.date.issued2020pt_BR
dc.identifier.issn1664-2295pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/250278pt_BR
dc.description.abstractThe effects of thrombolysis in seizure and epilepsy after acute ischemic stroke have been poorly explored. In this study, we examine risk factors and consequences of intravenous rt-PA for treatment of acute ischemic stroke. In a retrospective cohort study we evaluate risk factors for seizure and epilepsy after stroke thrombolysis, as well as the impact of seizures and epilepsy in outcome of stroke patients. In our cohort, mean age of patients was 67.2 years old (SD = 13.1) and 79 of them (51.6%) were male and. Initial NIHSS mean score were 10.95 (SD = 6.25). Three months NIHSS mean score was 2.09 (SD = 3.55). Eighty seven (56.9%) patients were mRS of 0–1 after thrombolysis. Hemorrhagic transformation was observed in 22 (14.4%) patients. Twenty-one (13.7%) patients had seizures and 15 (9.8%) patients developed epilepsy after thrombolysis. Seizures were independently associated with hemorrhagic transformation (OR = 3.26; 95% CI = 1.08–9.78; p = 0.035) and with mRS >= 2 at 3 months after stroke (OR = 3.51; 95% CI = 1.20–10.32; p = 0.022). Hemorrhagic transformation (OR = 3.55; 95% CI = 1.11–11.34; p = 0.033) and mRS >= 2 at 3 months (OR = 5.82; 95% CI = 1.45–23.42; p = 0.013) were variables independently associated with post-stroke epilepsy. In our study, independent risks factors for poor outcome in stroke thrombolysis were age (OR = 1.03; 95% CI = 1.01–1.06; p = 0.011), higher NIHSS (OR = 1.08; 95% CI = 1.03– 1.14; p = 0.001), hemorrhagic transformation (OR = 2.33; 95% CI = 1.11–4.76; p = 0.024), seizures (OR = 3.07; 95% CI = 1.22–7.75; p = 0.018) and large cortical area (ASPECTS <= 7) (OR = 2.04; 95% CI = 1.04–3.84; p = 0.036). Concluding, in this retrospective cohort study, the neurological impairment after thrombolysis (but not before) and hemorrhagic transformation remained independent risk factors for seizures or post-stroke epilepsy after thrombolysis. Moreover, we observed that seizures emerged as an independent risk factor for poor outcome after thrombolysis therapy in stroke patients (OR = 3.07; 95% CI = 1.22–7.75; p = 0.018).en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofFrontiers in neurology. [Lausanne]. Vol. 10 (2020), 1256, 10 p.pt_BR
dc.rightsOpen Accessen
dc.subjectReperfusãopt_BR
dc.subjectReperfusion therapyen
dc.subjectPost-stroke epilepsyen
dc.subjectEpilepsiapt_BR
dc.subjectAcute seizuresen
dc.subjectAcidente vascular cerebralpt_BR
dc.subjectConvulsõespt_BR
dc.subjectStroke outcomeen
dc.subjectAtivador de plasminogênio tecidualpt_BR
dc.subjectrt-PAen
dc.titleRisk factors for epilepsy after thrombolysis for ischemic stroke : a cohort studypt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001149719pt_BR
dc.type.originEstrangeiropt_BR


Thumbnail
   

Este item está licenciado na Creative Commons License

Mostrar registro simples