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dc.contributor.authorKlein, Mariana de Oliveirapt_BR
dc.contributor.authorRibeiro, Alice Taglianipt_BR
dc.contributor.authorFagundes, Nelson Jurandi Rosapt_BR
dc.contributor.authorMatte, Ursula da Silveirapt_BR
dc.contributor.authorFaccini, Lavinia Schulerpt_BR
dc.date.accessioned2022-09-01T05:00:27Zpt_BR
dc.date.issued2018pt_BR
dc.identifier.issn1415-4757pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/248406pt_BR
dc.description.abstractInsulin-like growth factor (IGF-1) is an important peptide hormone involved in the reproduction and fetal development of mammals, and it is suggested that it may influence the human twinning rate. This study aimed to test such possible association, investigating the genetic polymorphisms IGF1 (CA)n and IGFBP3 rs2854744 in the population from Candido Godoi (CG), a small city located in the South of Brazil that has a high prevalence of twin births. A case-control study was performed comprising a total of 39 cases (representing about 40% of the mothers of twins who were born in CG after 1995) and 214 controls (mothers of non-twin children), 97 of whom were living in CG while 117 were living in Porto Alegre. DNA was extracted from blood leucocytes and genotyping was performed. According to the statistical analyses, there was no significant difference in the frequencies of both studied genetic polymorphisms when comparing case group with control group. Thus, our results pointed to a lack of association between IGF1 (CA)n and IGFBP3 rs2854744 polymorphisms and twin births in CG, but further investigations in other populations with different characteristics must be performed to confirm the role of IGF-I in human twinning.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofGenetics and molecular biology. Ribeirão Preto. Vol. 41, no. 4, (Oct./Dec. 2018), p. 775-780pt_BR
dc.rightsOpen Accessen
dc.subjectInsulin-like growth factoren
dc.subjectInsulinapt_BR
dc.subjectFounder effecten
dc.subjectMicrossatélitept_BR
dc.subjectReproduçãopt_BR
dc.subjectMicrosatelliteen
dc.subjectGêmeospt_BR
dc.subjectReproductionen
dc.subjectCândido Godói (RS)pt_BR
dc.subjectTwinningen
dc.titleLack of association between genetic polymorphisms in IGF1 and IGFBP3 with twin births in a Brazilian population (Cândido Godói, Rio Grande do Sul)pt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001101801pt_BR
dc.type.originNacionalpt_BR


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