Atividade do Nucleus Reuniens é necessária para a reconsolidação de uma memória de medo contextual

Abstract

Memory reconsolidation is the process by which a consolidated memory can changed or disrupt by amnesic agents or behavioral interferences. This process require the activity of many neural structures conform the behavior task. In aversive memories pre-frontal cortex and hippocampus activity is critical to correct reconsolidation of the memory trace. Nucleus reuniens is the largest nucleus of midline thalamic nuclei and makes a bridge of communication between mPFC and HP. In this work we tested the effects of the excitatory activity and protein synthesis on NR during the reactivation of aversive memory on the reconsolidation process. We found a critic role of excitatory activity of NR in the reconsolidation of memory, but we not found any effect of protein synthesis of NR in the phenomena. We conclude that there is a modulator effect of NR during the reactivation that can affect the reconsolidation of the memory.