Obsessive-compulsive symptoms, polygenic risk score, and thalamic development in children from the Brazilian High-Risk Cohort for Mental Conditions (BHRCS)
dc.contributor.author | Salto, Ana Beatriz Ravagnani | pt_BR |
dc.contributor.author | Santoro, Marcos Leite | pt_BR |
dc.contributor.author | Hoexter, Marcelo Queiroz | pt_BR |
dc.contributor.author | Jackowski, Andrea Parolin | pt_BR |
dc.contributor.author | Pan, Pedro Mario | pt_BR |
dc.contributor.author | Rosário, Maria Conceição do | pt_BR |
dc.contributor.author | Belangero, Síntia Iole Nogueira | pt_BR |
dc.contributor.author | Alvarenga, Pedro Gomes de | pt_BR |
dc.contributor.author | Doretto, Victoria Fogaça | pt_BR |
dc.contributor.author | Fumo, Afonso Mazine Tiago | pt_BR |
dc.contributor.author | Batistuzzo, Marcelo Camargo | pt_BR |
dc.contributor.author | Barros, Pedro Macul Ferreira de | pt_BR |
dc.contributor.author | Timpano, Kiara R. | pt_BR |
dc.contributor.author | Ota, Vanessa Kiyomi Arashiro | pt_BR |
dc.contributor.author | Rohde, Luis Augusto Paim | pt_BR |
dc.contributor.author | Miguel, Eurípedes Constantino | pt_BR |
dc.contributor.author | Leckman, James F. | pt_BR |
dc.contributor.author | Zugman, André | pt_BR |
dc.date.accessioned | 2022-08-21T04:39:42Z | pt_BR |
dc.date.issued | 2021 | pt_BR |
dc.identifier.issn | 1664-0640 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/247685 | pt_BR |
dc.description.abstract | Background: Thalamic volume measures have been linked to obsessive-compulsive disorder (OCD) in children and adolescents. However, it is unclear if alterations in thalamic volumes occur before or after symptom onset and if there is a relation to the presence of sub-clinical obsessive-compulsive symptoms (OCS). Here, we explore the relationship between OCS and the rate of thalamic volume change in a cohort of children and youth at high risk to develop a mental disorder. A secondary aim was to determine if there is a relationship between OCS and the individual’s OCD polygenic risk score (OCD-PRS) and between the rate of thalamic volume change and the OCD-PRS. Methods: The sample included 378 children enrolled in the longitudinal Brazilian High-Risk Cohort for Mental Conditions. Participants were assessed for OCS and the symmetrized percent change (SPC) of thalamic volume across two time-points separated by 3 years, along with the OCD-PRS. Zero-altered negative binomial models were used to analyze the relationship between OCS and thalamic SPC. Multiple linear regressions were used to examine the relationship between thalamic SPC and OCD-PRS. Results: A significant relationship between OCS and the right thalamus SPC (p = 0.042) was found. There was no significant relationship between changes in thalamic volume SPC and OCD-PRS. Conclusions: The findings suggest that changes in the right thalamic volume over the course of 3 years in children may be associated to OCS. Future studies are needed to confirm these results and further characterize the specific nature of OCS symptoms associated with thalamic volumes. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Frontiers in Psychiatry. Lausanne. Vol. 12 (2021), 673595, 8 p. | pt_BR |
dc.rights | Open Access | en |
dc.subject | Obsessive-compulsive disorder | en |
dc.subject | Transtorno obsessivo-compulsivo | pt_BR |
dc.subject | MRI | en |
dc.subject | Imageamento por ressonância magnética | pt_BR |
dc.subject | Tálamo | pt_BR |
dc.subject | Magnetic resonance imaging | en |
dc.subject | Herança multifatorial | pt_BR |
dc.subject | Thalamus | en |
dc.subject | Neuroimagem | pt_BR |
dc.subject | Obsessive-compulsive symptoms | en |
dc.subject | Polygenic risk score | en |
dc.subject | OCD-PRS | en |
dc.subject | Neuroimaging | en |
dc.title | Obsessive-compulsive symptoms, polygenic risk score, and thalamic development in children from the Brazilian High-Risk Cohort for Mental Conditions (BHRCS) | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001147816 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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