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dc.contributor.authorZortéa, Maxcielpt_BR
dc.contributor.authorBeltran Serrano, Gerardo Viniciopt_BR
dc.contributor.authorAlves, Rael Lopespt_BR
dc.contributor.authorVicuña Serrano, Paul Corneliopt_BR
dc.contributor.authorTorres, Iraci Lucena da Silvapt_BR
dc.contributor.authorFregni, Felipept_BR
dc.contributor.authorCaumo, Wolneipt_BR
dc.date.accessioned2022-08-21T04:39:12Zpt_BR
dc.date.issued2021pt_BR
dc.identifier.issn2045-2322pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/247671pt_BR
dc.description.abstractSpectral power density (SPD) indexed by electroencephalogram (EEG) recordings has recently gained attention in elucidating neural mechanisms of chronic pain syndromes and medication use. We compared SPD variations between 15 fibromyalgia (FM) women in use of opioid in the last three months (73.33% used tramadol) with 32 non-users. EEG data were obtained with Eyes Open (EO) and Eyes Closed (EC) resting state. SPD peak amplitudes between EO-EC were smaller in opioid users in central theta, central beta, and parietal beta, and at parietal delta. However, these variations were positive for opioid users. Multivariate analyses of variance (ANOVAs) revealed that EO-EC variations in parietal delta were negatively correlated with the disability due to pain, and central and parietal beta activity variations were positively correlated with worse sleep quality. These clinical variables explained from 12.5 to 17.2% of SPD variance. In addition, central beta showed 67% sensitivity / 72% specificity and parietal beta showed 73% sensitivity/62% specificity in discriminating opioid users from non-users. These findings suggest oscillations in EEG might be a sensitive surrogate marker to screen FM opioid users and a promising tool to understand the effects of opioid use and how these effects relate to functional and sleep-related symptoms.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofScientific reports. London. Vol. 11 (2021), 22716, p. 13 p.pt_BR
dc.rightsOpen Accessen
dc.subjectFibromialgiapt_BR
dc.subjectBiomarcadorespt_BR
dc.subjectAnalgesicos opióidespt_BR
dc.subjectEletroencefalografiapt_BR
dc.titleSpectral power density analysis of the resting-state as a marker of the central effects of opioid use in fibromyalgiapt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001148022pt_BR
dc.type.originEstrangeiropt_BR


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