A Brazilian cohort of patients with immuno-mediated chronic inflammatory diseases infected by SARS-CoV-2 (ReumaCoV-Brasil Registry) : protocol for a prospective, observational study
dc.contributor.author | Marques, Cláudia Diniz Lopes | pt_BR |
dc.contributor.author | Kakehasi, Adriana Maria | pt_BR |
dc.contributor.author | Gomides, Ana Paula Monteiro | pt_BR |
dc.contributor.author | Paiva, Eduardo dos Santos | pt_BR |
dc.contributor.author | Reis Neto, Edgard Torres dos | pt_BR |
dc.contributor.author | Pileggi, Gecilmara Cristina Salviato | pt_BR |
dc.contributor.author | Provenza, José Roberto | pt_BR |
dc.contributor.author | Mota, Licia Maria Henrique da | pt_BR |
dc.contributor.author | Xavier, Ricardo Machado | pt_BR |
dc.contributor.author | Ferreira, Gilda Aparecida | pt_BR |
dc.contributor.author | Pinheiro, Marcelo Medeiros | pt_BR |
dc.date.accessioned | 2022-08-19T04:43:17Z | pt_BR |
dc.date.issued | 2020 | pt_BR |
dc.identifier.issn | 1929-0748 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/247340 | pt_BR |
dc.description.abstract | Background: Patients with immune-mediated rheumatic diseases (IMRD) are at increased risk of infections, including significant morbidity and high mortality. Considering the potential for unfavorable outcomes of SARS-CoV-2 infection in patients with IMRD, several questions were raised regarding the impact of COVID-19 at the start of the pandemic. Objective: This paper presents the protocol of a study that aims to prospectively evaluate patients with IMRD and a confirmed COVID-19 diagnosis (using criteria provided by the Brazilian Ministry of Health). Methods: The study comprised a prospective, observational cohort (patients with IMRD and COVID-19) and a comparison group (patients with only IMRD), with a follow-up time of 6 months to evaluate differences in health outcomes. The primary outcomes will be changes in IMRD disease activity after SARS-CoV-2 infection at 4 time points: (1) at baseline, (2) within 4-6 weeks after infection, (3) at 3 months after the second assessment (±15 days), and (4) at 6 months (±15 days). The secondary outcomes will be the progression rate to moderate or severe forms of COVID-19, need for intensive care unit admission and mechanical ventilation, death, and therapeutic changes related to IMRD. Two outcomes—pulmonary and thromboembolic events in patients with both IMRD and SARS-CoV-2 infection—are of particular interest and will be monitored with close attention (clinical, laboratory, and function tests as well as imaging). Results: Recruitment opened in May 2020, with 1300 participants recruited from 43 sites as of November 2020. Patient recruitment will conclude by the end of December 2020, with follow-up occurring until April 2021. Data analysis is scheduled to start after all inclusion data have been collected, with an aim to publish a peer-reviewed paper in December 2020. Conclusions: We believe this study will provide clinically relevant data on the general impact of COVID-19 on patients with IMRD. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | JMIR research protocols. Toronto. Vol. 9, no. 12 (2020), e24357. 12 p. | pt_BR |
dc.rights | Open Access | en |
dc.subject | SARS-CoV-2 | pt_BR |
dc.subject | Prospective study | en |
dc.subject | Immune-mediated rheumatic diseases | en |
dc.subject | Doenças reumáticas | pt_BR |
dc.subject | Registry | en |
dc.subject | Inflamação | pt_BR |
dc.subject | Doença crônica | pt_BR |
dc.subject | Brazil | en |
dc.subject | Inflammatory | en |
dc.subject | COVID-19 | pt_BR |
dc.subject | Chronic disease | en |
dc.subject | Mortalidade | pt_BR |
dc.subject | Cohort | en |
dc.subject | Morbidade | pt_BR |
dc.subject | Immunology | en |
dc.subject | Infection rate | en |
dc.subject | Mortality | en |
dc.subject | Morbidity | en |
dc.title | A Brazilian cohort of patients with immuno-mediated chronic inflammatory diseases infected by SARS-CoV-2 (ReumaCoV-Brasil Registry) : protocol for a prospective, observational study | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001146479 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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