Chagas disease and SARS-CoV-2 coinfection does not lead to worse in-hospital outcomes
dc.contributor.author | Molina, Israel | pt_BR |
dc.contributor.author | Rodrigues, Fernanda D'Athayde | pt_BR |
dc.contributor.author | Moreira, Leila Beltrami | pt_BR |
dc.contributor.author | Ferreira, Maria Angelica Pires | pt_BR |
dc.contributor.author | Polanczyk, Carisi Anne | pt_BR |
dc.contributor.author | Nunes, Maria do Carmo Pereira | pt_BR |
dc.date.accessioned | 2022-07-28T04:44:38Z | pt_BR |
dc.date.issued | 2021 | pt_BR |
dc.identifier.issn | 2045-2322 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/245575 | pt_BR |
dc.description.abstract | Chagas disease (CD) continues to be a major public health burden in Latina America. Information on the interplay between COVID-19 and CD is lacking. Our aim was to assess clinical characteristics and in-hospital outcomes of patients with CD and COVID-19, and to compare it to non-CD patients. Consecutive patients with confrmed COVID-19 were included from March to September 2020. Genetic matching for sex, age, hypertension, diabetes mellitus and hospital was performed in a 4:1 ratio. Of the 7018 patients who had confrmed COVID-19, 31 patients with CD and 124 matched controls were included (median age 72 (64–80) years-old, 44.5% were male). At baseline, heart failure (25.8% vs. 9.7%) and atrial fbrillation (29.0% vs. 5.6%) were more frequent in CD patients than in the controls (p< 0.05). C-reactive protein levels were lower in CD patients compared with the controls (55.5 [35.7, 85.0] vs. 94.3 [50.7, 167.5] mg/dL). In-hospital management, outcomes and complications were similar between the groups. In this large Brazilian COVID-19 Registry, CD patients had a higher prevalence of atrial fbrillation and chronic heart failure compared with non-CD controls, with no diferences in-hospital outcomes. The lower C-reactive protein levels in CD patients require further investigation. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Scientific reports. London. Vol. 11 (2021), 20289, 9 p. | pt_BR |
dc.rights | Open Access | en |
dc.subject | Doença de Chagas | pt_BR |
dc.subject | SARS-CoV-2 | pt_BR |
dc.subject | Hospitalização | pt_BR |
dc.title | Chagas disease and SARS-CoV-2 coinfection does not lead to worse in-hospital outcomes | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001146180 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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