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dc.contributor.authorPuma, Enver Miguel Oruropt_BR
dc.contributor.authorPardo, Grace Violeta Espinozapt_BR
dc.contributor.authorLucion, Aldo Boltenpt_BR
dc.contributor.authorCalcagnotto, Maria Elisapt_BR
dc.contributor.authorIdiart, Marco Aurelio Pirespt_BR
dc.date.accessioned2022-02-22T05:06:27Zpt_BR
dc.date.issued2020pt_BR
dc.identifier.issn1072-0502pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/235424pt_BR
dc.description.abstractDuring the first ten postnatal days (P), infant rodents can learn olfactory preferences for novel odors if they are paired with thermo-tactile stimuli that mimic components of maternal care. After P10, the thermo-tactile pairing becomes ineffective for conditioning. The current explanation for this change in associative learning is the alteration in the norepinephrine (NE) inputs from the locus coeruleus (LC) to the olfactory bulb (OB) and the anterior piriform cortex (aPC). By combining patchclamp electrophysiology and computational simulations, we showed in a recent work that a transitory high responsiveness of the OB-aPC circuit to the maternal odor is an alternative mechanism that could also explain early olfactory preference learning and its cessation after P10. That result relied solely on the maturational properties of the aPC pyramidal cells. However, the GABAergic system undergoes important changes during the same period. To address the importance of the maturation of the GABAergic system for early olfactory learning, we incorporated data from the GABA inputs, obtained from in vitro patch-clamp experiment in the aPC of rat pups aged P5–P7 reported here, to the model proposed in our previous publication. In the younger than P10 OB-aPC circuit with GABA synaptic input, the number of responsive aPC pyramidal cells to the conditioned maternal odor was amplified in 30% compared to the circuit without GABAergic input. When compared with the circuit with other younger than P10 OB-aPC circuit with adult GABAergic input profile, this amplification was 88%. Together, our results suggest that during the olfactory preference learning in younger than P10, the GABAergic synaptic input presumably acts by depolarizing the aPC pyramidal neurons in such a way that it leads to the amplification of the pyramidal neurons response to the conditioned maternal odor. Furthermore, our results suggest that during this developmental period, the aPC pyramidal cells themselves seem to resolve the apparent lack of GABAergic synaptic inhibition by a strong firing adaptation in response to increased depolarizing inputs.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofLearning & memory. Cold Spring Harbor. Vol. 27, no. 12 (Dec. 2020), p. 493-502pt_BR
dc.rightsOpen Accessen
dc.subjectPercepção olfatóriapt_BR
dc.subjectAprendizagempt_BR
dc.subjectBulbo olfatóriopt_BR
dc.subjectGABAérgicospt_BR
dc.titleThe maturational characteristics of the GABA input in the anterior piriform cortex may also contribute to the rapid learning of the maternal odor during the sensitive periodpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001120254pt_BR
dc.type.originEstrangeiropt_BR


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