Amyloid-dependent and amyloid-independent effects of Tau in individuals without dementia
dc.contributor.author | Therriault, Joseph | pt_BR |
dc.contributor.author | Pascoal, Tharick Ali | pt_BR |
dc.contributor.author | Sefranek, Marcus | pt_BR |
dc.contributor.author | Mathotaarachchi, Sulantha Sanjeewa | pt_BR |
dc.contributor.author | Benedet, Andréa L. | pt_BR |
dc.contributor.author | Chamoun, Mira | pt_BR |
dc.contributor.author | Lussier, Firoza Z. | pt_BR |
dc.contributor.author | Tissot, Cecile | pt_BR |
dc.contributor.author | Bellaver, Bruna | pt_BR |
dc.contributor.author | Ferreira, Pâmela Lukasewicz | pt_BR |
dc.contributor.author | Zimmer, Eduardo Rigon | pt_BR |
dc.contributor.author | Saha-Chaudhuri, Paramita | pt_BR |
dc.contributor.author | Gauthier, Serge G. | pt_BR |
dc.contributor.author | Rosa Neto, Pedro | pt_BR |
dc.date.accessioned | 2021-12-07T04:31:21Z | pt_BR |
dc.date.issued | 2021 | pt_BR |
dc.identifier.issn | 2328-9503 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/232648 | pt_BR |
dc.description.abstract | Objective: To investigate the relationship between the topography of amyloid-β plaques, tau neurofibrillary tangles, and the overlap between the two, with cognitive dysfunction in individuals without dementia. Methods: We evaluated 154 individuals who were assessed with amyloid-β PET with [18F]AZD4694, tau-PET with [18F]MK6240, structural MRI, and neuropsychological testing. We also evaluated an independent cohort of 240 individuals who were assessed with amyloid-β PET with [18F]Florbetapir, tau-PET with [18F]Flortaucipir, structural MRI, and neuropsychological testing. Using the VoxelStats toolbox, we conducted voxel-wise linear regressions between amyloid-PET, tau-PET, and their interaction with cognitive function, correcting for age, sex, and years of education. Results: In both cohorts, we observed that tau-PET standardized uptake value ratio in medial temporal lobes was associated with clinical dementia rating Sum of Boxes (CDR-SoB) scores independently of local amyloid-PET uptake (FWE corrected at p < 0.001). We also observed in both cohorts that in regions of the neocortex, associations between neocortical tau-PET and clinical function were dependent on local amyloid-PET (FWE corrected at p < 0.001). Interpretation: In medial temporal brain regions, characterized by the accumulation of tau pathology in the absence of amyloid-β, tau had direct associations with cognitive dysfunction. In brain regions characterized by the accumulation of both amyloid-β and tau pathologies such as the posterior cingulate and medial frontal cortices, tau’s relationship with cognitive dysfunction was dependent on local amyloid-β concentrations. Our results provide evidence that amyloid-β in Alzheimer’s disease influences cognition by potentiating the deleterious effects of tau pathology. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Annals of clinical and translational neurology. [Hoboken]. Vol. 8, no. 10 (Oct. 2021), p. 2083-2092 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Peptídeos beta-amilóides | pt_BR |
dc.subject | Proteínas tau | pt_BR |
dc.subject | Disfunção cognitiva | pt_BR |
dc.subject | Tauopatias | pt_BR |
dc.title | Amyloid-dependent and amyloid-independent effects of Tau in individuals without dementia | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001134276 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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