Synergistic effect of ibuprofen with itraconazole and fluconazole against Cryptococcus neoformans
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Date
2017Author
Advisor
Academic level
Graduation
Subject
Abstract
The present study investigated the association of the non-steroidal anti-inflammatory drug ibuprofen with itraconazole, fluconazole and amphotericin B against Cryptococcus neformans isolates. The minimal inhibitory concentration (MIC) was found according to M27-A3 protocol and the in vitro interactions were evaluated using a checkerboard microdilution method. Synergism was demonstrated between azoles and ibuprofen for most isolates. However, no synergistic effects were seen when amphotericin B ...
The present study investigated the association of the non-steroidal anti-inflammatory drug ibuprofen with itraconazole, fluconazole and amphotericin B against Cryptococcus neformans isolates. The minimal inhibitory concentration (MIC) was found according to M27-A3 protocol and the in vitro interactions were evaluated using a checkerboard microdilution method. Synergism was demonstrated between azoles and ibuprofen for most isolates. However, no synergistic effects were seen when amphotericin B was combined with ibuprofen. Therefore, our results suggest that ibuprofen presents clinical potential when combined with azole drugs in the treatment of cryptococcosis. ...
Institution
Universidade Federal do Rio Grande do Sul. Faculdade de Farmácia. Curso de Farmácia.
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