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Synergistic effect of ibuprofen with itraconazole and fluconazole against Cryptococcus neoformans

dc.contributor.advisorMezzari, Adelinapt_BR
dc.contributor.authorRocha, Letícia Fernandes dapt_BR
dc.date.accessioned2021-10-21T04:29:11Zpt_BR
dc.date.issued2017pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/231022pt_BR
dc.description.abstractThe present study investigated the association of the non-steroidal anti-inflammatory drug ibuprofen with itraconazole, fluconazole and amphotericin B against Cryptococcus neformans isolates. The minimal inhibitory concentration (MIC) was found according to M27-A3 protocol and the in vitro interactions were evaluated using a checkerboard microdilution method. Synergism was demonstrated between azoles and ibuprofen for most isolates. However, no synergistic effects were seen when amphotericin B was combined with ibuprofen. Therefore, our results suggest that ibuprofen presents clinical potential when combined with azole drugs in the treatment of cryptococcosis.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.rightsOpen Accessen
dc.subjectCryptococcus neoformansen
dc.subjectFarmáciapt_BR
dc.subjectSynergismen
dc.subjectFluconazoleen
dc.subjectItraconazole,en
dc.subjectIbuprofenen
dc.titleSynergistic effect of ibuprofen with itraconazole and fluconazole against Cryptococcus neoformanspt_BR
dc.typeTrabalho de conclusão de graduaçãopt_BR
dc.identifier.nrb001066072pt_BR
dc.degree.grantorUniversidade Federal do Rio Grande do Sulpt_BR
dc.degree.departmentFaculdade de Farmáciapt_BR
dc.degree.localPorto Alegre, BR-RSpt_BR
dc.degree.date2017pt_BR
dc.degree.graduationFarmáciapt_BR
dc.degree.levelgraduaçãopt_BR


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