Synergistic effect of ibuprofen with itraconazole and fluconazole against Cryptococcus neoformans
dc.contributor.advisor | Mezzari, Adelina | pt_BR |
dc.contributor.author | Rocha, Letícia Fernandes da | pt_BR |
dc.date.accessioned | 2021-10-21T04:29:11Z | pt_BR |
dc.date.issued | 2017 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/231022 | pt_BR |
dc.description.abstract | The present study investigated the association of the non-steroidal anti-inflammatory drug ibuprofen with itraconazole, fluconazole and amphotericin B against Cryptococcus neformans isolates. The minimal inhibitory concentration (MIC) was found according to M27-A3 protocol and the in vitro interactions were evaluated using a checkerboard microdilution method. Synergism was demonstrated between azoles and ibuprofen for most isolates. However, no synergistic effects were seen when amphotericin B was combined with ibuprofen. Therefore, our results suggest that ibuprofen presents clinical potential when combined with azole drugs in the treatment of cryptococcosis. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.rights | Open Access | en |
dc.subject | Cryptococcus neoformans | en |
dc.subject | Farmácia | pt_BR |
dc.subject | Synergism | en |
dc.subject | Fluconazole | en |
dc.subject | Itraconazole, | en |
dc.subject | Ibuprofen | en |
dc.title | Synergistic effect of ibuprofen with itraconazole and fluconazole against Cryptococcus neoformans | pt_BR |
dc.type | Trabalho de conclusão de graduação | pt_BR |
dc.identifier.nrb | 001066072 | pt_BR |
dc.degree.grantor | Universidade Federal do Rio Grande do Sul | pt_BR |
dc.degree.department | Faculdade de Farmácia | pt_BR |
dc.degree.local | Porto Alegre, BR-RS | pt_BR |
dc.degree.date | 2017 | pt_BR |
dc.degree.graduation | Farmácia | pt_BR |
dc.degree.level | graduação | pt_BR |
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