Mostrar el registro sencillo del ítem
Effects of vitamin D administration on nociception and spinal cord pro-oxidant and antioxidant markers in a rat model of neuropathic pain
dc.contributor.author | Santos, Maria do Carmo Quevedo | pt_BR |
dc.contributor.author | Silva, Thaisla Cristiane Borella da | pt_BR |
dc.contributor.author | Silva, Francielle Braz Oliveira da | pt_BR |
dc.contributor.author | Siebert, Cassiana | pt_BR |
dc.contributor.author | Kroth, Adarly | pt_BR |
dc.contributor.author | Silveira, Elza Maria Santos da | pt_BR |
dc.contributor.author | Wyse, Angela Terezinha de Souza | pt_BR |
dc.contributor.author | Partata, Wania Aparecida | pt_BR |
dc.date.accessioned | 2021-10-06T04:13:27Z | pt_BR |
dc.date.issued | 2021 | pt_BR |
dc.identifier.issn | 0100-879X | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/230520 | pt_BR |
dc.description.abstract | Reactive oxygen species (ROS) are involved in neuropathic pain, a complicated condition after nerve tissue lesion. Vitamin D appears to improve symptoms of pain and exhibits antioxidant properties. We investigated the effects of oral administration of vitamin D3, the active form of vitamin D, on nociception, the sciatic functional index (SFI), and spinal cord pro-oxidant and antioxidant markers in rats with chronic constriction injury (CCI) of the sciatic nerve, a model of neuropathic pain. Vitamin D3 (500 IU/kg per day) attenuated the CCI-induced decrease in mechanical withdrawal threshold and thermal withdrawal latency (indicators of antinociception) and SFI. The vitamin prevented increased lipid hydroperoxide levels in injured sciatic nerve without change to total antioxidant capacity (TAC). Vitamin D3 prevented increased lipid hydroperoxide, superoxide anion generation (SAG), and hydrogen peroxide (H2O2) levels in the spinal cord, which were found in rats without treatment at 7 and 28 days post-CCI. A significant negative correlation was found between mechanical threshold and SAG and between mechanical threshold and H2O2 at day 7. Vitamin D3 also prevented decreased spinal cord total thiols content. There was an increase in TAC in the spinal cord of vitamin-treated CCI rats, compared to CCI rats without treatment only at 28 days. No significant changes were found in body weight and blood parameters of hepatic and renal function. These findings demonstrated, for first time, that vitamin D modulated pro-oxidant and antioxidant markers in the spinal cord. Since antinociception occurred in parallel with oxidative changes in the spinal cord, the oxidative changes may have contributed to vitamin D-induced antinociception. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Brazilian journal of medical and biological research. Ribeirão Preto. Vol. 54, no. 10 (2021), e11207, 11 p. | pt_BR |
dc.rights | Open Access | en |
dc.subject | Total thiol content | en |
dc.subject | Vitamina D | pt_BR |
dc.subject | Superoxide anion generation | en |
dc.subject | Neuralgia | pt_BR |
dc.subject | Total antioxidant capacity | en |
dc.subject | Colecalciferol | pt_BR |
dc.subject | Sciatic functional index | en |
dc.subject | Nervo isquiático | pt_BR |
dc.subject | Antioxidantes | pt_BR |
dc.subject | Mechanical withdrawal threshold | en |
dc.subject | Espécies reativas de oxigênio | pt_BR |
dc.subject | Thermal withdrawal latency | en |
dc.title | Effects of vitamin D administration on nociception and spinal cord pro-oxidant and antioxidant markers in a rat model of neuropathic pain | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001131246 | pt_BR |
dc.type.origin | Nacional | pt_BR |
Ficheros en el ítem
Este ítem está licenciado en la Creative Commons License
![](/themes/Mirage2Novo//images/lume/cc.png)
-
Artículos de Periódicos (39541)Ciencias Biologicas (3081)