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dc.contributor.authorOliveira, Luis Flávio Souza dept_BR
dc.contributor.authorFuentefria, Alexandre Meneghellopt_BR
dc.contributor.authorKlein, Fernanda da Silvapt_BR
dc.contributor.authorMachado, Michel Mansurpt_BR
dc.date.accessioned2021-09-24T04:22:30Zpt_BR
dc.date.issued2014pt_BR
dc.identifier.issn1517-8382pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/230188pt_BR
dc.description.abstractIn the last times, focus on plant research has increased all over the world. Euphorbia tirucalli L., a plant known popularly as Aveloz, and originally used in Africa, has been drawing attention for its use in the United States and Latin America, both for use as an ornamental plant and as a medicinal plant. E. tirucalli L. is a member of the family Euphorbiaceae and contains many diterpenoids and triterpenoids, in particular phorbol esters, apparently the main constituent of this plant, which are assumed to be responsible for their activities in vivo and in vitro. The in vitro antifungal activities of Euphorbia tirucalli (L.) against opportunistic yeasts were studied using microbroth dilution assay. The results showed that aqueous extract and latex preparation were effective against ten clinical strains of Cryptococcus neoformans in vitro (Latex and extract MIC range of 3.2 - > 411 g/mL). Aiming the safe use in humans, the genotoxic effects of E. tirucalli were evaluated in human leukocytes cells. Our data show that both aqueous extract and latex preparation have no genotoxic effect in human leukocytes cells in vitro. Although the results cannot be extrapolated by itself for use in vivo, they suggest a good perspective for a therapeutic application in future. In conclusion, our results show that the aqueous extract and latex preparation from E. tirucalli L. are antifungal agents effectives against several strains of C. neoformans and do not provoke DNA damage in human leukocyte cells, considering the concentrations tested.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofBrazilian journal of microbiology. Vol. 45, no. 4 (Out/Dez 2014), p. 1349-1355pt_BR
dc.rightsOpen Accessen
dc.subjectEuphorbia tirucalli L.en
dc.subjectFarmáciapt_BR
dc.subjectAvelozen
dc.subjectAntifungalen
dc.subjectCryptococcus neoformansen
dc.titleAntifungal activity against Cryptococcus neoformans strains and genotoxicity assessment in human leukocyte cells of Euphorbia tirucalli L.pt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000955224pt_BR
dc.type.originNacionalpt_BR


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