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dc.contributor.authorSouza, Sonimar dept_BR
dc.contributor.authorReuter, Cézane Priscilapt_BR
dc.contributor.authorAndersen, Lars Bopt_BR
dc.contributor.authorLima, Rodrigo Antunespt_BR
dc.contributor.authorPfeiffer, Karin Allorpt_BR
dc.contributor.authorMello, Elza Daniel dept_BR
dc.contributor.authorGaya, Anelise Reispt_BR
dc.contributor.authorFranke, Silvia Isabel Rechpt_BR
dc.contributor.authorRenner, Jane Dagmar Pollopt_BR
dc.date.accessioned2021-09-14T04:27:47Zpt_BR
dc.date.issued2020pt_BR
dc.identifier.issn1530-0447pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/229736pt_BR
dc.description.abstractThe associations of renal, hepatic, and hematologic markers with metabolic risk (MR) have already been shown in adolescents. However, it is still controversial which marker best predicts metabolic changes in youth. The aim of this study was to verify the association of MR with alanine aminotransferase (ALT), aspartate aminotransferase (AST), uric acid, and hemoglobin (Hb) in adolescents. METHODS: We evaluated 1713 Brazilian adolescents aged 10 to 17 years. MR was calculated using a continuous metabolic risk score, including the sum of Z-scores of waist circumference, systolic blood pressure, fasting glucose, high-density lipoproteins, triglycerides, and cardiorespiratory fitness. Cutoff points were set for MR prediction for five metabolic components (ALT, AST, AST/ ALT ratio, uric acid, and Hb). RESULTS: MR was strongly associated with increased uric acid (odds ratio [OR]: 2.50; 95% confidence interval [CI]: 1.74–3.59), ALT (OR: 2.64; 95% CI: 1.63–4.27), and AST levels (OR: 2.53; 95% CI: 1.24–5.18). Uric acid was shown to be the best predictor for MR (sensitivity: 55.79%; specificity: 61.35%; area under the curve: 0.616). CONCLUSION: Elevated hepatic, renal, and hematological markers were associated with MR in adolescents, especially ALT, AST, and uric acid levels.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofPediatric Research. Jersey City, NJ. Vol. 80, n.6, (Dez. 2020), p. 945–949pt_BR
dc.rightsOpen Accessen
dc.subjectObesidadept_BR
dc.subjectAdolescentespt_BR
dc.subjectMetabolismopt_BR
dc.titleMetabolic risk associated with liver enzymes, uric acid, and hemoglobin in adolescentspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001131129pt_BR
dc.type.originEstrangeiropt_BR


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