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dc.contributor.authorGomes, Julia do Amaralpt_BR
dc.contributor.authorSgarioni, Eduardapt_BR
dc.contributor.authorVieira, Igor Araújopt_BR
dc.contributor.authorFraga, Lucas Rosapt_BR
dc.contributor.authorProlla, Patrícia Ashtonpt_BR
dc.contributor.authorTerças, Ana Cláudia Pereirapt_BR
dc.contributor.authorSilva, Juliana Herrero dapt_BR
dc.contributor.authorRibeiro, Bethânia de Freitas Rodriguespt_BR
dc.contributor.authorGalera, Marcial Francispt_BR
dc.contributor.authorOliveira, Thalita Mara dept_BR
dc.contributor.authorCarvalho, Maria Denise Fernandespt_BR
dc.contributor.authorCarvalho, Isabella Fernandespt_BR
dc.contributor.authorFaccini, Lavinia Schulerpt_BR
dc.contributor.authorVianna, Fernanda Sales Luizpt_BR
dc.date.accessioned2021-09-03T04:27:27Zpt_BR
dc.date.issued2021pt_BR
dc.identifier.issn2235-2988pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/229526pt_BR
dc.description.abstractCongenital Zika Syndrome (CZS) occurs in up to 42% of individuals exposed to ZIKV prenatally. Deregulation in gene expression and protein levels of components of the p53 signaling pathway, such as p53 and MDM2, due to ZIKV infection has been reported. Here, we evaluate functional polymorphisms in genes of the p53 signaling pathway as risk factors to CZS. Forty children born with CZS and forty-eight children exposed to ZIKV, but born without congenital anomalies were included in this study. Gestational and sociodemographic information as well as the genotypic and allelic frequencies of functional polymorphisms in TP53, MDM2, MIR605 and LIF genes were compared between the two groups. We found children with CZS exposed predominantly in the first trimester and controls in the third trimester (p<0.001). Moreover, children with CZS were predominantly from families with a lower socioeconomic level (p=0.008). We did not find a statistically significant association between the investigated polymorphisms and development of CZS; however, by comparing individuals with CZS and lissencephaly or without lissencephaly, we found a significative difference in the allelic frequencies of the TP53 rs1042522, which is associated with a more potent p53-induced apoptosis (p=0.007). Our findings suggest that the TP53 rs1042522 polymorphism should be better investigate as a genetic risk factor for the development of lissencephaly in children with CZS.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofFrontiers in cellular and infection microbiology. Lausanne. Vol. 11 (July 2021), 641413, 8 p.pt_BR
dc.rightsOpen Accessen
dc.subjectCongenital abnormalitiesen
dc.subjectInfecção por Zika viruspt_BR
dc.subjectGenes p53pt_BR
dc.subjectZika virus infectionen
dc.subjectTeratogensen
dc.subjectPolimorfismo genéticopt_BR
dc.subjectGenetic polymorphismen
dc.subjectSuscetibilidade a doençaspt_BR
dc.subjectTeratógenospt_BR
dc.subjectDisease susceen
dc.subjectRisk factorsen
dc.subjectApoptosisen
dc.subjectLissencephalyen
dc.titleFunctional polymorphisms in the p53 pathway genes on the genetic susceptibility to zika virus teratogenesispt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001130645pt_BR
dc.type.originEstrangeiropt_BR


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