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dc.contributor.authorBem, Andreza Fabro dept_BR
dc.contributor.authorKrolow, Rachelpt_BR
dc.contributor.authorFarias, Hémelin Resendept_BR
dc.contributor.authorRezende, Victória Linden dept_BR
dc.contributor.authorGelain, Daniel Penspt_BR
dc.contributor.authorMoreira, Jose Claudio Fonsecapt_BR
dc.contributor.authorDuarte, João Miguel das Nevespt_BR
dc.contributor.authorOliveira, Jade dept_BR
dc.date.accessioned2021-04-06T04:19:11Zpt_BR
dc.date.issued2021pt_BR
dc.identifier.issn1662-453Xpt_BR
dc.identifier.urihttp://hdl.handle.net/10183/219431pt_BR
dc.description.abstractThe incidence of metabolic disorders, as well as of neurodegenerative diseases—mainly the sporadic forms of Alzheimer’s and Parkinson’s disease—are increasing worldwide. Notably, obesity, diabetes, and hypercholesterolemia have been indicated as early risk factors for sporadic forms of Alzheimer’s and Parkinson’s disease. These conditions share a range of molecular and cellular features, including protein aggregation, oxidative stress, neuroinflammation, and blood-brain barrier dysfunction, all of which contribute to neuronal death and cognitive impairment. Rodent models of obesity, diabetes, and hypercholesterolemia exhibit all the hallmarks of these degenerative diseases, and represent an interesting approach to the study of the phenotypic features and pathogenic mechanisms of neurodegenerative disorders. We review the main pathological aspects of Alzheimer’s and Parkinson’s disease as summarized in rodent models of obesity, diabetes, and hypercholesterolemia.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofFrontiers in neuroscience. Lausanne. Vol. 14 (Jan. 2021), 604150, 22 p.pt_BR
dc.rightsOpen Accessen
dc.subjectAlzheimer’s diseaseen
dc.subjectDoença de Alzheimerpt_BR
dc.subjectDoença de Parkinsonpt_BR
dc.subjectParkinson’s diseaseen
dc.subjectHypercholesterolemiaen
dc.subjectObesidadept_BR
dc.subjectObesityen
dc.subjectDiabetes mellituspt_BR
dc.subjectHipercolesterolemiapt_BR
dc.subjectDiabetesen
dc.subjectRodent modelsen
dc.subjectDoenças neurodegenerativas : Metabolismopt_BR
dc.subjectNeurodegenerationen
dc.titleAnimal models of metabolic disorders in the study of neurodegenerative diseases : an overviewpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001123265pt_BR
dc.type.originEstrangeiropt_BR


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