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dc.contributor.authorBattistel, Ana Paulapt_BR
dc.contributor.authorRocha, Bruno Simas dapt_BR
dc.contributor.authorSantos, Maitê Telles dospt_BR
dc.contributor.authorDaudt, Liane Estevespt_BR
dc.contributor.authorMichalowski, Mariana Bohnspt_BR
dc.date.accessioned2021-03-16T04:26:23Zpt_BR
dc.date.issued2021pt_BR
dc.identifier.issn2531-1379pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/218912pt_BR
dc.description.abstractIntroduction To assess the frequency of allergic reactions to asparaginase (ASP) and possible risk factors for reactions in a cohort of pediatric patients. Method The study was performed based on retrospective data from patients under acute lymphoid leukemia treatment in a general university hospital located in southern Brazil. Information on patients who used ASP from 2010 to 2017 was collected. Allergic reactions were identified in electronic medical records. Results Among the 98 patients included in the study, 16 (16.3 %) experienced an allergic reaction to native l-asparaginase (L-ASP). Of the 22 patients (22.4 %) that received only intravenous (IV) administration of l-ASP, 10 (62.5 %) had allergic reactions, while 48 patients (49 %) received intramuscular (IM) administration and 28 (28.6 %) received IV and IM administrations. The occurrence of allergic reactions differed between the groups (p <  0.001), and IV administration was associated with allergic reactions. Association was also observed between the severity of the reaction and the route of administration, with the IM route associated with grade 2 and IV route associated with grade 3. Occurrence of allergic reactions was higher when the commercial formulation of l-ASP, Leuginase®, was used (p =  0.0009 in the analysis per patient and p =  0.0003 in the analysis per administration). Conclusions The IV administration and commercial Leuginase® presentation were associated with more allergic reactions in the study population, which corroborates the findings in the literature. The IV route was also associated with higher severity of reactions in the present study.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofHematology, transfusion and cell therapy. Rio de Janeiro. Vol. 43, no.1 (2021), p. 9-14pt_BR
dc.rightsOpen Accessen
dc.subjectAcute lymphoblastic leukemiaen
dc.subjectLeucemia-linfoma linfoblástico de células precursoraspt_BR
dc.subjectAsparaginaseen
dc.subjectCriançapt_BR
dc.subjectHypersensitivityen
dc.subjectAsparaginasept_BR
dc.subjectHipersensibilidadept_BR
dc.subjectChildrenen
dc.subjectFatores de riscopt_BR
dc.titleAllergic reactions to asparaginase : retrospective cohort study in pediatric patients with acute lymphoid leukemiapt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001123251pt_BR
dc.type.originNacionalpt_BR


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