Guanosine fast onset antidepressant-like effects in the olfactory bulbectomy mice model
dc.contributor.author | Almeida, Roberto Farina de | pt_BR |
dc.contributor.author | Barbosa, Camila Pocharski | pt_BR |
dc.contributor.author | Rodrigues, Ana Lucia Severo | pt_BR |
dc.contributor.author | Elisabetsky, Elaine | pt_BR |
dc.contributor.author | Souza, Diogo Onofre Gomes de | pt_BR |
dc.date.accessioned | 2020-12-09T04:11:50Z | pt_BR |
dc.date.issued | 2020 | pt_BR |
dc.identifier.issn | 2045-2322 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/216217 | pt_BR |
dc.description.abstract | The treatment of major depressive disorder (MDD) is still a challenge. In the search for novel antidepressants, glutamatergic neuromodulators have been investigated as possible fast-acting antidepressants. Innovative studies suggest that the purine cycle and/or the purinergic signaling can be dysregulated in MDD, and the endogenous nucleoside guanosine has gained attention due to its extracellular effects. This study aimed to verify if guanosine produces fast-onset effects in the wellvalidated, reliable and sensitive olfactory bulbectomy (OBX) model of depression. The involvement of the mTOR pathway, a key target for the fast-onset effect of ketamine, was also investigated. Results show that a single i.p. injection of guanosine, or ketamine, completely reversed the OBX-induced anhedonic-like behavior 24 or 48 h post treatment, as well as the short-term recognition memory impairment 48 h post treatment. The antidepressant-like effects of guanosine and ketamine were completely abolished by rapamycin. This study shows, for the first time, that guanosine, in a way similar to ketamine, is able to elicit a fast antidepressant response in the OBX model in mice. The results support the notion that guanosine represents a new road for therapeutic improvement in MDD. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Scientific reports. London. Vol. 10 (2020), 8429, 9 p. | pt_BR |
dc.rights | Open Access | en |
dc.subject | Transtorno depressivo maior | pt_BR |
dc.subject | Guanosina | pt_BR |
dc.subject | Bulbo olfatório | pt_BR |
dc.title | Guanosine fast onset antidepressant-like effects in the olfactory bulbectomy mice model | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001119026 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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