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dc.contributor.authorWang, Sijiapt_BR
dc.contributor.authorLewis Junior, Cecil M.pt_BR
dc.contributor.authorJakobsson, Mattiaspt_BR
dc.contributor.authorRamachandran, Sohinipt_BR
dc.contributor.authorRay, Nicolaspt_BR
dc.contributor.authorBedoya, Gabrielpt_BR
dc.contributor.authorRojas, Winstonpt_BR
dc.contributor.authorParra, María V.pt_BR
dc.contributor.authorMolina, Julio A.pt_BR
dc.contributor.authorGallo, Carlapt_BR
dc.contributor.authorMazzotti, Guidopt_BR
dc.contributor.authorPoletti, Giovannipt_BR
dc.contributor.authorHill, Kim R.pt_BR
dc.contributor.authorHurtado, Ana Magdalenapt_BR
dc.contributor.authorLabuda, Damianpt_BR
dc.contributor.authorKlitz, Williampt_BR
dc.contributor.authorBarrantes, Ramiropt_BR
dc.contributor.authorBortolini, Maria Cátirapt_BR
dc.contributor.authorSalzano, Francisco Mauropt_BR
dc.contributor.authorPetzl-Erler, Maria Luizapt_BR
dc.contributor.authorTsuneto, Luiza T.pt_BR
dc.contributor.authorLlop, Elenapt_BR
dc.contributor.authorRothhammer, Franciscopt_BR
dc.contributor.authorExcoffier, Laurentpt_BR
dc.contributor.authorFeldman, Marcus W.pt_BR
dc.contributor.authorRosenberg, Noah A.pt_BR
dc.contributor.authorRuiz-Linares, Andrespt_BR
dc.date.accessioned2010-05-05T04:15:48Zpt_BR
dc.date.issued2008pt_BR
dc.identifier.issn1553-7390pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/21545pt_BR
dc.description.abstractWe examined genetic diversity and population structure in the American landmass using 678 autosomal microsatellite markers genotyped in 422 individuals representing 24 Native American populations sampled from North, Central, and South America. These data were analyzed jointly with similar data available in 54 other indigenous populations worldwide, including an additional five Native American groups. The Native American populations have lower genetic diversity and greater differentiation than populations from other continental regions. We observe gradients both of decreasing genetic diversity as a function of geographic distance from the Bering Strait and of decreasing genetic similarity to Siberians—signals of the southward dispersal of human populations from the northwestern tip of the Americas. We also observe evidence of: (1) a higher level of diversity and lower level of population structure in western South America compared to eastern South America, (2) a relative lack of differentiation between Mesoamerican and Andean populations, (3) a scenario in which coastal routes were easier for migrating peoples to traverse in comparison with inland routes, and (4) a partial agreement on a local scale between genetic similarity and the linguistic classification of populations. These findings offer new insights into the process of population dispersal and differentiation during the peopling of the Americas.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofPlos Genetics. Cambridge. Vol. 3, n. 11 (Nov. 2007), p. 2049-2067pt_BR
dc.rightsOpen Accessen
dc.subjectGenética humanapt_BR
dc.subjectVariacao geneticapt_BR
dc.subjectAméricapt_BR
dc.titleGenetic variation and population structure in native americanspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000640514pt_BR
dc.type.originEstrangeiropt_BR


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