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dc.contributor.authorGuazzelli, Pedro Arendpt_BR
dc.contributor.authorSantos, Giordano Fabricio Cittolinpt_BR
dc.contributor.authorMartins, Leo Anderson Meirapt_BR
dc.contributor.authorGrings, Mateuspt_BR
dc.contributor.authorNonose, Yasminept_BR
dc.contributor.authorLazzarotto, Gabrielapt_BR
dc.contributor.authorNogara, Daniela Albugeript_BR
dc.contributor.authorSilva, Jussemara Souza dapt_BR
dc.contributor.authorFontella, Fernanda Urruthpt_BR
dc.contributor.authorWajner, Moacirpt_BR
dc.contributor.authorLeipnitz, Guilhianpt_BR
dc.contributor.authorSouza, Diogo Onofre Gomes dept_BR
dc.contributor.authorAssis, Adriano Martimbianco dept_BR
dc.date.accessioned2020-11-20T04:15:05Zpt_BR
dc.date.issued2020pt_BR
dc.identifier.issn1662-5099pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/215278pt_BR
dc.description.abstractAcute liver failure (ALF) implies a severe and rapid liver dysfunction that leads to impaired liver metabolism and hepatic encephalopathy (HE). Recent studies have suggested that several brain alterations such as astrocytic dysfunction and energy metabolism impairment may synergistically interact, playing a role in the development of HE. The purpose of the present study is to investigate early alterations in redox status, energy metabolism and astrocytic reactivity of rats submitted to ALF. Adult male Wistar rats were submitted either to subtotal hepatectomy (92% of liver mass) or sham operation to induce ALF. Twenty-four hours after the surgery, animals with ALF presented higher plasmatic levels of ammonia, lactate, ALT and AST and lower levels of glucose than the animals in the sham group. Animals with ALF presented several astrocytic morphological alterations indicating astrocytic reactivity. The ALF group also presented higher mitochondrial oxygen consumption, higher enzymatic activity and higher ATP levels in the brain (frontoparietal cortex). Moreover, ALF induced an increase in glutamate oxidation concomitant with a decrease in glucose and lactate oxidation. The increase in brain energy metabolism caused by astrocytic reactivity resulted in augmented levels of reactive oxygen species (ROS) and Poly [ADP-ribose] polymerase 1 (PARP1) and a decreased activity of the enzymes superoxide dismutase and glutathione peroxidase (GSH-Px). These findings suggest that in the early stages of ALF the brain presents a hypermetabolic state, oxidative stress and astrocytic reactivity, which could be in part sustained by an increase in mitochondrial oxidation of glutamate.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofFrontiers in molecular neuroscience. Lausanne. Vol. 12 (Jan. 2020), 327, 14 p.pt_BR
dc.rightsOpen Accessen
dc.subjectAcute liver failureen
dc.subjectFalência hepática agudapt_BR
dc.subjectEncefalopatia hepáticapt_BR
dc.subjectBrain energy metabolismen
dc.subjectEspécies reativas de oxigêniopt_BR
dc.subjectHepatic encephalopathyen
dc.subjectRedox homeostasisen
dc.subjectAstrócitospt_BR
dc.subjectEstresse oxidativopt_BR
dc.subjectMitochondriaen
dc.subjectGlial reactivityen
dc.subjectAmôniapt_BR
dc.titleAcute liver failure induces glial reactivity, oxidative stress and impairs brain energy metabolism in ratspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001116745pt_BR
dc.type.originEstrangeiropt_BR


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