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Effects of childhood trauma on BDNF and TBARS during crack-cocaine withdrawal
dc.contributor.author | Sordi, Anne Orgler | pt_BR |
dc.contributor.author | Diemen, Lisia von | pt_BR |
dc.contributor.author | Schuch, Silvia Bassani | pt_BR |
dc.contributor.author | Ornell, Felipe | pt_BR |
dc.contributor.author | Kapczinski, Flávio Pereira | pt_BR |
dc.contributor.author | Pfaffenseller, Bianca | pt_BR |
dc.contributor.author | Gubert, Carolina de Moura | pt_BR |
dc.contributor.author | Aguiar, Bianca Wollenhaupt de | pt_BR |
dc.contributor.author | Salum Junior, Giovanni Abrahão | pt_BR |
dc.contributor.author | Pechansky, Flavio | pt_BR |
dc.date.accessioned | 2020-11-19T04:15:35Z | pt_BR |
dc.date.issued | 2020 | pt_BR |
dc.identifier.issn | 1516-4446 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/215188 | pt_BR |
dc.description.abstract | Objective: To evaluate the association between childhood trauma (CT) and serum levels of brainderived neurotrophic factor (BDNF) and thiobarbituric acid-reactive substances (TBARS) during crackcocaine withdrawal. Method: Thirty-three male crack-cocaine users were recruited at admission to a public addiction treatment unit. Serum BDNF and TBARS levels were evaluated at intake and discharge. Information about drug use was assessed by the Addiction Severity Index-6th Version (ASI-6); CT was reported throughout the Childhood Trauma Questionnaire (CTQ). CTQ scores were calculated based on a latent analysis model that divided the sample into low-, medium-, and high-level trauma groups. Results: There was a significant increase in BDNF levels from admission to discharge, which did not differ across CT subgroups. For TBARS levels, we found a significant time vs. trauma interaction (F2,28 = 6.357, p = 0.005,Zp 2 = 0.312). In participants with low trauma level, TBARS decreased, while in those with a high trauma level, TBARS increased during early withdrawal. Conclusion: TBARS levels showed opposite patterns of change in crack-cocaine withdrawal according to baseline CT. These results suggest that CT could be associated with more severe neurological impairment during withdrawal. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Revista brasileira de psiquiatria. São Paulo. Vol. 42, n.2 (2020), p. 214-217 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Estresse oxidativo | pt_BR |
dc.subject | Childhood trauma | en |
dc.subject | Cocaína | pt_BR |
dc.subject | Cocaine | en |
dc.subject | Drug abuse | en |
dc.subject | Trauma psicológico | pt_BR |
dc.subject | BDNF | en |
dc.subject | Experiências adversas da infância | pt_BR |
dc.subject | Transtornos relacionados ao uso de substâncias | pt_BR |
dc.subject | Oxidative stress | en |
dc.subject | Fator neurotrófico derivado do encéfalo | pt_BR |
dc.title | Effects of childhood trauma on BDNF and TBARS during crack-cocaine withdrawal | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001118365 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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