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dc.contributor.authorKrampe, Susana Ferreirapt_BR
dc.contributor.authorAndrade, Nicole Pamplona Bueno dept_BR
dc.contributor.authorSilveira, Letícia Guimarães dapt_BR
dc.contributor.authorBrenol, Claiton Viegaspt_BR
dc.date.accessioned2020-08-08T03:46:21Zpt_BR
dc.date.issued2020pt_BR
dc.identifier.issn2163-9914pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/212769pt_BR
dc.description.abstractRheumatoid Arthritis (RA) is an inflammatory disease associated with high morbidity and increased cardiovascular disease, and Metabolic Syndrome (MS) is understood as a set of metabolic disorders that correlates with obesity and sedentary lifestyle. The aim of this study is to evaluate the prevalence of MS in a cohort of patients with RA and its correlation to specific factors of the disease. A retrospective cohort study was conducted with 283 patients with RA, followed at the Rheumatology Outpatient Clinic of the Hospital de Clínicas de Porto Alegre (HCPA) between 2008 and 2016; 187 continued to be followed and agreed to be reevaluated between January and November 2016. MS was defined according to the National Cholesterol Education Program and disease activity was assessed using the Disease Activity Score (DAS28). Clinical, biochemical, and anthropometric evaluations were conducted. The prevalence of MS in the first evaluation was 43.9% and, after 8 years, 59.4%. Increased waist circumference and blood pressures, elevated triglycerides and low High-Density Lipoprotein were the most frequent features of MS. The DAS28 was significantly lower in the reevaluation (p = 0.006). The prevalence of MS was higher at the end of 8 years; disease activity, as well as blood pressure, decreased during this period. Steroid use had also decreased at the end of follow-up. There was an increase of 15% of cases with MS in an 8-year follow-up cohort of patients, which was in agreement with the current literature and showed how the inflammatory process in RA is correlated to MS. The parameters of MS that varied the most were blood pressure, cholesterol and triglycerides. Ultimately, these parameters and disease activity must be observed closely in order to improve the prognosis of patients with RA.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofOpen journal of rheumatology and autoimmune diseases. Irvine. Vol. 10 (2020), p. 95-108pt_BR
dc.rightsOpen Accessen
dc.subjectRheumatoid arthritisen
dc.subjectArtrite reumatóidept_BR
dc.subjectMetabolic syndromeen
dc.subjectSíndrome metabólicapt_BR
dc.subjectPrevalênciapt_BR
dc.subjectMedical treatmenten
dc.subjectBody mass indexen
dc.subjectÍndice de massa corporalpt_BR
dc.subjectDisease activityen
dc.titlePrevalence and incidence of metabolic syndrome in a cohort of patients with rheumatoid arthritis : a correlation between body mass index and disease activitypt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001115843pt_BR
dc.type.originEstrangeiropt_BR


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