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dc.contributor.authorSilva Júnior, Walter Ferreira dapt_BR
dc.contributor.authorMenezes, Danielle Lima Bezerra dept_BR
dc.contributor.authorOliveira, Luana Carvalho dept_BR
dc.contributor.authorKoester, Leticia Schererpt_BR
dc.contributor.authorAlmeida, Patrícia Danielle Oliveira dept_BR
dc.contributor.authorLima, Emerson Silvapt_BR
dc.contributor.authorAzevedo, Eduardo Pereira dept_BR
dc.contributor.authorVeiga Junior, Valdir Florencio dapt_BR
dc.contributor.authorLima, Adley Antonini Neves dept_BR
dc.date.accessioned2020-08-04T03:38:31Zpt_BR
dc.date.issued2019pt_BR
dc.identifier.issn2218-273Xpt_BR
dc.identifier.urihttp://hdl.handle.net/10183/212564pt_BR
dc.description.abstractα, β amyrin (ABAM) is a natural mixture of pentacyclic triterpenes that has a wide range of biological activities. ABAM is isolated from the species of the Burseraceae family, in which the species Protium is commonly found in the Amazon region of Brazil. The aim of this work was to develop inclusion complexes (ICs) of ABAM and β-cyclodextrin (βCD) and hydroxypropyl-β-cyclodextrin (HPβCD) by physical mixing (PM) and kneading (KN) methods. Interactions between ABAM and the CD's as well as the formation of ICs were confirmed by physicochemical characterization in the solid state by Fourier transform infrared (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD), thermogravimetry (TG) and differential scanning calorimetry (DSC). Physicochemical characterization indicated the formation of ICs with both βCD and HPβCD. Such ICs were able to induce changes in the physicochemical properties of ABAM. In addition, the formation of ICs with cyclodextrins showed to be an effective and promising alternative to enhance the anti-inflammatory activity and safety of ABAM.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofBiomolecules. Basel. Vol. 9, n. 6 (2019), 241, [14 p.]pt_BR
dc.rightsOpen Accessen
dc.subjectFarmáciapt_BR
dc.subjectAmyrinen
dc.subjectCiclodextrinaspt_BR
dc.subjectCyclodextrinen
dc.subjectInclusion complexesen
dc.subjectAnti-inflamatóriospt_BR
dc.subjectAnti-inflammatoryen
dc.titleInclusion complexes of β and HPβ-cyclodextrin with α, β amyrin and in vitro anti-inflammatory activitypt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001115566pt_BR
dc.type.originEstrangeiropt_BR


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