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dc.contributor.authorLeitão, Cristiane Bauermannpt_BR
dc.contributor.authorNabinger, Gustavo Baldinopt_BR
dc.contributor.authorKrahe, Ana L. D.pt_BR
dc.contributor.authorBolson, Patrícia Borchardtpt_BR
dc.contributor.authorGerchman, Fernandopt_BR
dc.contributor.authorFriedman, Rogériopt_BR
dc.contributor.authorGross, Jorge Luizpt_BR
dc.contributor.authorCanani, Luis Henrique Santospt_BR
dc.date.accessioned2010-04-24T04:15:50Zpt_BR
dc.date.issued2008pt_BR
dc.identifier.issn0100-879Xpt_BR
dc.identifier.urihttp://hdl.handle.net/10183/21224pt_BR
dc.description.abstractThe aim of the present study was to analyze the frequency of K121Q polymorphism in the ENPP1 gene of Brazilian subjects according to ethnic origin and to determine its possible association with diabetes mellitus (DM) and/or diabetic complications. A cross-sectional study was conducted on 1027 type 2 DM patients and 240 anonymous blood donors (BD). Ethnicity was classified based on self-report of European and African descent. The Q allele frequency was increased in African descendant type 2 DM patients (KK = 25.9%, KQ = 48.2%, and QQ = 25.9%) and BD (KK = 22.0%, KQ = 53.8%, and QQ = 24.2%) compared to European descendant type 2 DM patients (KK = 62.7%, KQ = 33.3%, and QQ = 4.1%) and BD (KK = 61.0%, KQ = 35.6%, and QQ = 3.4%). However, there was no difference in genotype distribution or Q allele frequency between diabetic and non-diabetic subjects (European descendants: DM = 0.21 vs BD = 0.21, P = 0.966, and African descendants: DM = 0.50 vs BD = 0.51, P = 0.899). In addition, there were no differences in clinical, laboratory or insulin resistance indices among the three genotypes. The prevalence of DM complications was also similar. In conclusion, K121Q polymorphism is more common among Afro-Brazilian descendants regardless of glycemic status or insulin sensitivity indices. Likewise, insulin sensitivity and DM chronic complications appear not to be related to the polymorphism in this sample.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 41, no. 3 (Mar. 2008), p. 229-234pt_BR
dc.rightsOpen Accessen
dc.subjectENPP1 polymorphismen
dc.subjectDiabetes mellitus tipo 2pt_BR
dc.subjectEthnicityen
dc.subjectComplicações do diabetespt_BR
dc.subjectType 2 diabetes mellitusen
dc.subjectEtnicidadept_BR
dc.subjectPolimorfismo genéticopt_BR
dc.titleThe role of K121Q ENPP1 polymorphism in diabetes mellitus and its complicationspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000656414pt_BR
dc.type.originNacionalpt_BR


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