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dc.contributor.authorCastro, Simone Martins dept_BR
dc.contributor.authorSporleder, Heloísa Coutinhopt_BR
dc.contributor.authorSchröeder, Regina Barbosapt_BR
dc.contributor.authorSantos, A.pt_BR
dc.contributor.authorGarcia, V.pt_BR
dc.contributor.authorNeumann, Jorgept_BR
dc.contributor.authorCosta, S.C.B.pt_BR
dc.date.accessioned2010-04-24T04:15:28Zpt_BR
dc.date.issued2003pt_BR
dc.identifier.issn0100-879Xpt_BR
dc.identifier.urihttp://hdl.handle.net/10183/21144pt_BR
dc.description.abstractWe have determined the number of circulating T, B and natural killer cells in renal transplant recipients in order to detect changes during cytomegalovirus (CMV) infections. Serial blood samples were taken from 61 patients on standard triple immunosuppression therapy (cyclosporin A, azathioprine and prednisone). Using two-color flow cytometry analysis, the absolute number of CD3+, CD4+, CD8+, CD19+, CD3+HLA-DR+ and CD16+56+ cells was determined. Fortyeight patients (78.7%) developed active CMV infection, and all of them subsequently recovered. Twenty of the infected patients (32.8%) presented symptoms compatible with CMV disease during the infectious process. The number of lymphocytes and their main subpopulations were normal before the onset of CMV disease. During the disease there was a decrease followed by a significant increase (P<0.005) in the number of CD3+, CD4+, CD8+ and CD3+HLADR+ cells. No significant changes were observed in natural killer cells or B lymphocytes during the disease. We conclude, as observed in all viremic patients recovering from infection, that recovery is associated with an increase in the number of T cell subsets. The monitoring of different lymphocyte subsets along with antigenemia can be extremely useful in the detection of patients at high risk of developing CMV symptoms, allowing the early introduction of antiviral therapy or the reduction of immunosuppression therapy.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 36, no. 6 (June 2003), p. 795-805pt_BR
dc.rightsOpen Accessen
dc.subjectTransplantationen
dc.subjectLinfócitospt_BR
dc.subjectCytomegalovirusen
dc.subjectTransplantespt_BR
dc.subjectCitomegaloviruspt_BR
dc.subjectAntigenemiaen
dc.subjectT lymphocytesen
dc.titleLymphocyte subpopulations during cytomegalovirus disease in renal transplant recipientspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000379452pt_BR
dc.type.originNacionalpt_BR


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