Association studies between -1185A/G von Willebrand factor gene polymorphism and coronary artery disease
dc.contributor.author | Simon, Daniel | pt_BR |
dc.contributor.author | Paludo, Crislaine A. | pt_BR |
dc.contributor.author | Ghisleni, Gabriele Cordenonzi | pt_BR |
dc.contributor.author | Manfroi, Waldomiro Carlos | pt_BR |
dc.contributor.author | Roisenberg, Israel | pt_BR |
dc.date.accessioned | 2010-04-24T04:15:27Z | pt_BR |
dc.date.issued | 2003 | pt_BR |
dc.identifier.issn | 0100-879X | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/21131 | pt_BR |
dc.description.abstract | High levels of von Willebrand factor (vWF) have been associated with cardiovascular disease. The A allele of the -1185A/G polymorphism in the 5'-regulatory region of the vWF gene was associated with the highest plasma vWF levels in a normal population. To examine the association between -1185A/G polymorphism and coronary artery disease (CAD), 173 Brazilian Caucasian subjects submitted to coronary angiography were studied. Of these, 57 (33%) had normal coronary arteries (control group) and 116 (67%) had CAD (patient group). Plasma vWF levels were higher in patients (145 U/dl) than in controls (130 U/dl), but the differences were significant only for O blood group subjects. Polymerase chain reaction amplification of the 864-bp vWF promoter region followed by AccII restriction digestion was used to identify the -1185A/G genotypes. The -1185A allele frequency was 43.1% in patients and 44.7% in controls. Allele and genotype frequencies were not significantly different between patients and controls. No association was observed between the -1185A/G genotypes and plasma vWF levels in patients or controls. These results suggest that -1185A/G polymorphism is not an independent risk factor for CAD. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Brazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 36, no. 6 (June 2003), p. 709-714 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Von Willebrand factor | en |
dc.subject | Doenças cardiovasculares | pt_BR |
dc.subject | Fatores de risco | pt_BR |
dc.subject | Coronary artery disease | en |
dc.subject | DNA polymorphisms | en |
dc.subject | Risk factor | en |
dc.title | Association studies between -1185A/G von Willebrand factor gene polymorphism and coronary artery disease | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000376546 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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