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dc.contributor.authorSouza, Lívia Hartmann dept_BR
dc.contributor.authorSalum Junior, Giovanni Abrahãopt_BR
dc.contributor.authorMosqueiro, Bruno Pazpt_BR
dc.contributor.authorCaldieraro, Marco Antonio Knobpt_BR
dc.contributor.authorGuerra, Tadeu Assispt_BR
dc.contributor.authorFleck, Marcelo Pio de Almeidapt_BR
dc.date.accessioned2020-03-12T04:13:51Zpt_BR
dc.date.issued2016pt_BR
dc.identifier.issn0165-0327pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/206698pt_BR
dc.description.abstractBackground Treatment-resistant depression (TRD) is an extremely prevalent clinical condition. Although Interpersonal Psychotherapy (IPT) is an established treatment for uncomplicated depression, its effectiveness has never before been studied in patients with TRD in real-world settings. We investigate IPT as an adjunct strategy to treatment as usual (TAU) for TRD patients in a pragmatic, randomized, controlled trial. Methods A total of 40 adult patients with TRD (satisfying the criteria for major depressive disorder despite adequate antidepressant treatment) were recruited from a tertiary care facility for this pragmatic trial and blinded to the evaluator. Patients were randomized to one of two treatment conditions: (1) TAU – pharmacotherapy freely chosen by the clinician (n=23) and (2) TAU+IPT (n=17). Assessments were performed at weeks 8, 12, 19 and 24. Changes in the estimated means of the Hamilton Depression Rating Scale score were the primary outcome measure. Secondary outcomes included patient-rated scales and quality of life scales. We used a linear mixed model to compare changes over time between the two groups. Results Both treatments lead to improvements in depressive symptoms from baseline to week 24 with no significant between group differences in either primary: TAU (mean difference: 4.57; CI95%: 0.59–8.55; d=0.73) vs. IPT+TAU (mean difference: 5.86, CI95%: 1.50–10.22; d=0.93) or secondary outcomes. Limitations Our relatively small sample limits our ability to detect differences between treatments. Conclusions Both treatments lead to equal improvements in depressive symptoms. We found no evidence to support adding IPT to pharmacotherapy in patients with TRD.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofJournal of affective disorders. Amsterdam. Vol. 193 (Mar. 2016), p. 373-380.pt_BR
dc.rightsOpen Accessen
dc.subjectDepressionen
dc.subjectDepressãopt_BR
dc.subjectTreatment-resistant depressionen
dc.subjectPsicoterapiapt_BR
dc.subjectInterpersonal psychotherapyen
dc.subjectEnsaio clínico controlado aleatóriopt_BR
dc.subjectRandomized pragmatic clinical trialen
dc.titleInterpersonal psychotherapy as add-on for treatment-resistant depression : a pragmatic randomized controlled trialpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001013982pt_BR
dc.type.originEstrangeiropt_BR


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