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dc.contributor.authorSilva, André Macedo Serafim dapt_BR
dc.contributor.authorWinckler, Pablo Breapt_BR
dc.contributor.authorSaute, Jonas Alex Moralespt_BR
dc.contributor.authorZanoteli, Edmarpt_BR
dc.date.accessioned2020-01-16T04:10:25Zpt_BR
dc.date.issued2019pt_BR
dc.identifier.issn2328-9503pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/204378pt_BR
dc.description.abstractObjective: ANO5-related myopathy is an important cause of limb-girdle muscular dystrophy (LGMD) and hyperCKemia. The main descriptions have emerged from European cohorts, and the burden of the disease worldwide is unclear. We provide a detailed characterization of a large Brazilian cohort of ANO5 patients. Methods: A national cross-sectional study was conducted to describe clinical, histopathological, radiological, and molecular features of patients carrying recessive variants in ANO5. Correlation of clinical and genetic characteristics with different phenotypes was studied. Results: Thirty-seven patients from 34 nonrelated families with recessive mutations of ANO5 were identified. The most common phenotype was LGMD, observed in 25 (67.5%) patients, followed by pseudometabolic presentation in 7 (18.9%) patients, isolated asymptomatic hyperCKemia in 4 (10.8%) patients, and distal myopathy in a single patient. Nine patients presented axial involvement, including one patient with isolated axial weakness. The most affected muscles according to MRI were the semimembranosus and gastrocnemius, but paraspinal and abdominal muscles, when studied, were involved in most patients. Fourteen variants in ANO5 were identified, and the c.191dupA was present in 19 (56%) families. Sex, years of disease, and the presence of loss-of-function variants were not associated with specific phenotypes. Interpretation: We present the largest series of anoctaminopathy outside Europe. The most common European founder mutation c.191dupA was very frequent in our population. Gender, disease duration, and genotype did not determine the phenotype.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofAnnals of clinical and translational neurology. Hoboken. vol. 6, no. 7 (2019), p. 1225-1238pt_BR
dc.rightsOpen Accessen
dc.subjectDoencas muscularespt_BR
dc.subjectGenéticapt_BR
dc.titleClinical and molecular findings in a cohort of ANO5-related myopathypt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001109511pt_BR
dc.type.originEstrangeiropt_BR


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