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dc.contributor.authorSilveira, Elza Maria Santos dapt_BR
dc.contributor.authorKroth, Adarlypt_BR
dc.contributor.authorSantos, Maria do Carmo Quevedopt_BR
dc.contributor.authorSilva, Thaisla Cristiane Borella dapt_BR
dc.contributor.authorSilveira, Diane Pereirapt_BR
dc.contributor.authorRiffel, Ana Paula Konzenpt_BR
dc.contributor.authorScheid, Tainapt_BR
dc.contributor.authorTrapp, Márciapt_BR
dc.contributor.authorPartata, Wania Aparecidapt_BR
dc.date.accessioned2020-01-15T04:16:18Zpt_BR
dc.date.issued2019pt_BR
dc.identifier.issn0100-879Xpt_BR
dc.identifier.urihttp://hdl.handle.net/10183/204316pt_BR
dc.description.abstractThe present study aimed to analyze age-related changes to motor coordination, balance, spinal cord oxidative biomarkers in 3-, 6-, 18-, 24-, and 30-month-old rats. The effects of low-intensity exercise on these parameters were also analyzed in 6-, 18-, and 24-month-old rats. Body weight, blood glucose, total cholesterol, and high-density lipoprotein (HDL) cholesterol were assessed for all rats. The soleus muscle weight/body weight ratio was used to estimate skeletal muscle mass loss. Body weight increased until 24 months; only 30-month-old rats exhibited decreased blood glucose and increased total cholesterol and HDL cholesterol. The soleus muscle weight/body weight ratio increased until 18 months, followed by a small decrease in old rats. Exercise did not change any of these parameters. Stride length and step length increased from adult to middle age, but decreased at old age. Stride width increased while the sciatic functional index decreased in old rats. Performance in the balance beam test declined with age. While gait did not change, balance improved after exercise. Aging increased superoxide anion generation, hydrogen peroxide levels, total antioxidant capacity, and superoxide dismutase activity while total thiol decreased and lipid hydroperoxides did not change. Exercise did not significantly change this scenario. Thus, aging increased oxidative stress in the spinal cord, which may be associated with age-induced changes in gait and balance. Regular low-intensity exercise is a good alternative for improving age-induced changes in balance, while beneficial effects on gait and spinal cord oxidative biomarkers cannot be ruled out because of the small number of rats investigated (n=5 or 6/group).en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofBrazilian journal of medical and biological research. Ribeirão Preto. Vol. 52, no. 7 (July 2019), e8429, 13 p.pt_BR
dc.rightsOpen Accessen
dc.subjectSuperoxide anion generationen
dc.subjectEnvelhecimentopt_BR
dc.subjectEspécies reativas de oxigêniopt_BR
dc.subjectHydrogen peroxideen
dc.subjectTotal thiol contenten
dc.subjectSuperóxidospt_BR
dc.subjectExercíciopt_BR
dc.subjectLipid hydroperoxide levelsen
dc.subjectTotal antioxidant capacityen
dc.subjectSuperoxide dismutaseen
dc.titleAge-related changes and effects of regular low-intensity exercise on gait, balance, and oxidative biomarkers in the spinal cord of Wistar ratspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001103818pt_BR
dc.type.originNacionalpt_BR


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