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dc.contributor.authorMoreira, Andréa Janzpt_BR
dc.contributor.authorRodrigues, Graziellapt_BR
dc.contributor.authorBona, Silvia Reginapt_BR
dc.contributor.authorCerski, Carlos Thadeu Schmidtpt_BR
dc.contributor.authorMarroni, Claudio Augustopt_BR
dc.contributor.authorMauriz, José Luizpt_BR
dc.contributor.authorGonzález-Gallego, Javierpt_BR
dc.contributor.authorMarroni, Norma Anair Possapt_BR
dc.date.accessioned2019-11-08T03:44:23Zpt_BR
dc.date.issued2015pt_BR
dc.identifier.issn2214-7500pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/201454pt_BR
dc.description.abstractHepatocellular carcinoma (HCC) is the third most frequent cause of cancer deaths through-out the world. This study was aimed to analyze oxidative stress and cell damage in amultistage model of liver carcinogenesis induced by diethylnitrosamine (DEN) in rats.Male Wistar rats weighing 145–150 g were divided into three groups: control, precan-cerous lesions (PL) (which received 100 mg DEN once a week every 6 weeks up to 28weeks), and advanced HCC (50 mg DEN once/twice per week up to 19 weeks). Lipid per-oxidation (TBARS), superoxide dismutase (SOD) activity, and expression of transforminggrowth factor-1 beta (TGF)-1 , endothelial and inducible nitric oxide syntahese (eNOS,iNOS), NADPH quinone oxireductase (NQO)-1, nuclear factor erythroid 2-related factor(NrF)2, kelch-like ECH-associated protein (Keap)1 and heat shock protein (HSP)70 weremeasured. TBARS concentration was augmented in the PL and advanced HCC groups. SODactivity, TGF-1 and Nrf2 expression were higher in animals with precancerous lesions.In advanced HCC, expression of NQO1 and iNOS increased while there was a decrease inHPS70 expression. Data obtained provide evidence for the differential activation of pro-teins involved in oxidative stress and cell damage during progression of carcinogenesis inan animal model of HCC.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofToxicology reports. [Ireland]. Vol. 2 (2015), p. 333-340pt_BR
dc.rightsOpen Accessen
dc.subjectEstresse oxidativopt_BR
dc.subjectCarcinoma hepatocelularpt_BR
dc.subjectÓxido nítrico sintasept_BR
dc.subjectDietilnitrosaminapt_BR
dc.subjectAnimaispt_BR
dc.subjectRatos Wistarpt_BR
dc.titleOxidative stress and cell damage in a model of precancerouslesions and advanced hepatocellular carcinoma in ratspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001070471pt_BR
dc.type.originEstrangeiropt_BR


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