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dc.contributor.authorJacovas, Vanessa Cristinapt_BR
dc.contributor.authorRovaris, Diego Luizpt_BR
dc.contributor.authorPeréz, Orlandopt_BR
dc.contributor.authorAzevedo, Soledad dept_BR
dc.contributor.authorMacedo, Gabriel Souzapt_BR
dc.contributor.authorSandoval, José R.pt_BR
dc.contributor.authorSalazar Granara, Alberto Alcibiadespt_BR
dc.contributor.authorVillena, Mercedespt_BR
dc.contributor.authorDugoujon, Jean-Michelpt_BR
dc.contributor.authorMachado, Rafael Bissopt_BR
dc.contributor.authorPetzi-Erler, Maria Luizapt_BR
dc.contributor.authorSalzano, Francisco Mauropt_BR
dc.contributor.authorProlla, Patrícia Ashtonpt_BR
dc.contributor.authorRamallo, Virgíniapt_BR
dc.contributor.authorBortolini, Maria Cátirapt_BR
dc.date.accessioned2019-10-12T03:53:39Zpt_BR
dc.date.issued2015pt_BR
dc.identifier.issn1932-6203pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/200605pt_BR
dc.description.abstractThe diversity of the five single nucleotide polymorphisms located in genes of the TP53 pathway (TP53, rs1042522; MDM2, rs2279744; MDM4, rs1563828; USP7, rs1529916; and LIF, rs929271) were studied in a total of 282 individuals belonging to Quechua, Aymara, Chivay, Cabanaconde, Yanke, Taquile, Amantani, Anapia, Uros, Guarani Ñandeva, and Guarani Kaiowá populations, characterized as Native American or as having a high level (> 90%) of Native American ancestry. In addition, published data pertaining to 100 persons from five other Native American populations (Surui, Karitiana, Maya, Pima, and Piapoco) were analyzed. The populations were classified as living in high altitude ( 2,500 m) or in lowlands (< 2,500 m). Our analyses revealed that alleles USP7-G, LIF-T, and MDM2-T showed significant evidence that they were selected for in relation to harsh environmental variables related to high altitudes. Our results show for the first time that alleles of classical TP53 network genes have been evolutionary co-opted for the successful human colonization of the Andes.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofPlos One [recurso eletrônico]. San Francisco. Vol. 10, no. 9 (Sep. 2015), 1-15 p. e0137823pt_BR
dc.rightsOpen Accessen
dc.subjectVariacao geneticapt_BR
dc.subjectNativos : Americapt_BR
dc.subjectAndes, Cordilheira dos, Regiãopt_BR
dc.titleGenetic variations in the TP53 pathway in native americans strongly suggest adaptation to the high altitudes of the Andespt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001016437pt_BR
dc.type.originEstrangeiropt_BR


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