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dc.contributor.authorCopetti, Cristianept_BR
dc.contributor.authorFranco, Fernanda Wouterspt_BR
dc.contributor.authorMachado, Eduarda da Rosapt_BR
dc.contributor.authorSoquetta, Marcela Brombergerpt_BR
dc.contributor.authorQuatrin, Andréiapt_BR
dc.contributor.authorRamos, Vitor de Mirandapt_BR
dc.contributor.authorMoreira, Jose Claudio Fonsecapt_BR
dc.contributor.authorEmanuelli, Tatianapt_BR
dc.contributor.authorSautter, Cláudia Kaehlerpt_BR
dc.contributor.authorPenna, Neidi Garciapt_BR
dc.date.accessioned2019-08-30T02:35:28Zpt_BR
dc.date.issued2018pt_BR
dc.identifier.issn2090-0724pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/198687pt_BR
dc.description.abstractFew studies investigated the biological effects of American grape cultivars. We investigated the metabolic response after acute consumption of grape juice or wine from Bordo grapes (Vitis labrusca) in a placebo-controlled crossover study with fifteen healthy volunteers. Blood samples were collected 1 hour after the intake of 100 mL of water, juice, or wine to measure TBARS, ABTS, FRAP, glucose, and uric acid levels. To evaluate differences in cellular response, intracellular reactive species production (DCFH-DA) and metabolic mitochondrial viability (MTT) were assessed after exposure of human neuron-like cells (SH-SY5Y) to juice or wine. Glycemia was reduced after juice or wine consumption, whereas blood levels of uric acid were reduced after juice consumption but increased after wine consumption. Juice and wine consumption reduced plasma lipid peroxidation and increased plasma antioxidant capacity (ABTS and FRAP assays). Furthermore, juice inhibited H2O2-induced intracellular production of reactive species (RS) and increased the viability of SH-SY5Y cells. In contrast, wine (dealcoholized) exhibited a per se effect by inducing the production of RS and reducing cell viability. )ese results indicate a positive impact of acute consumption of Bordo juice and wine on human oxidative status, whereas only juice had protective effects against oxidative stress-induced cytotoxicity.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofJournal of Nutrition and Metabolism. London. Vol. 2018 (2018), 4384012, 11 p.pt_BR
dc.rightsOpen Accessen
dc.subjectVitispt_BR
dc.subjectVinhopt_BR
dc.subjectEstresse oxidativopt_BR
dc.subjectEspécies reativas de oxigêniopt_BR
dc.titleAcute consumption of bordo grape juice and wine improves serum antioxidant status in healthy individuals and inhibits reactive oxygen species production in human neuron-like cellspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001098692pt_BR
dc.type.originEstrangeiropt_BR


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