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dc.contributor.authorSantos, Patríciapt_BR
dc.contributor.authorHerrmann, Ana Paulapt_BR
dc.contributor.authorElisabetsky, Elainept_BR
dc.contributor.authorPiato, Angelo Luis Stapassolipt_BR
dc.date.accessioned2019-07-31T02:30:14Zpt_BR
dc.date.issued2019pt_BR
dc.identifier.issn1516-4446pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/197547pt_BR
dc.description.abstractObjective: Anxiety disorders are highly prevalent and the efficacy of the available anxiolytic drugs is less than desired. Adverse effects also compromise patient quality of life and adherence to treatment. Accumulating evidence shows that the pathophysiology of anxiety and related disorders is multifactorial, involving oxidative stress, neuroinflammation, and glutamatergic dysfunction. The aim of this review was to evaluate data from animal studies and clinical trials showing the anxiolytic effects of agents whose mechanisms of action target these multiple domains. Methods: The PubMed database was searched for multitarget agents that had been evaluated in animal models of anxiety, as well as randomized double-blind placebo-controlled clinical trials of anxiety and/or anxiety related disorders. Results: The main multitarget agents that have shown consistent anxiolytic effects in various animal models of anxiety, as well in clinical trials, are agomelatine, N-acetylcysteine (NAC), and omega-3 fatty acids. Data from clinical trials are preliminary at best, but reveal good safety profiles and tolerance to adverse effects. Conclusion: Agomelatine, NAC and omega-3 fatty acids show beneficial effects in clinical conditions where mainstream treatments are ineffective. These three multitarget agents are considered promising candidates for innovative, effective, and better-tolerated anxiolytics.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofRevista brasileira de psiquiatria = Brazilian journal of psychiatry. São Paulo. Vol. 41, n. 2 (mar./abr. 2019), p. 168-178pt_BR
dc.rightsOpen Accessen
dc.subjectAnsiolíticospt_BR
dc.subjectAnxietyen
dc.subjectAgomelatineen
dc.subjectÁcidos graxos ômega-3pt_BR
dc.subjectN-acetylcysteineen
dc.subjectAcetilcisteínapt_BR
dc.subjectOmega-3 fatty acidsen
dc.titleAnxiolytic properties of compounds that counteract oxidative stress, neuroinflammation, and glutamatergic dysfunction : a reviewpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001093319pt_BR
dc.type.originNacionalpt_BR


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