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dc.contributor.authorHentges, Cláudia Reginapt_BR
dc.contributor.authorSilveira, Rita de Cássia dos Santospt_BR
dc.contributor.authorProcianoy, Renato Soibelmannpt_BR
dc.date.accessioned2019-05-11T02:37:47Zpt_BR
dc.date.issued2013pt_BR
dc.identifier.issn1098-8785pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/194152pt_BR
dc.description.abstractBackground Angiogenic and antiangiogenic factors are altered in pregnant women with preeclampsia (PE), but the pattern of expression of these factors in their newborns remains unknown. Objective This study aims to measure vascular endothelial growth factor (VEGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) levels in preterm neonates born to mothers with PE. Methods Neonates with birth weight < 2,000 g and gestational age 34 weeks were included and divided into the following two groups: born to mothers with PE and without PE. Blood was collected from neonates within the first 72 hours of life. VEGF and sFlt-1 levels were measured using the enzyme-linked immunosorbent assay method. Results A total of 88 neonates were included (37 born to mothers with PE and 51 born to mothers without PE), with a mean gestational age of 29.12 2.96 weeks and birth weight of 1,223.80 417.48 g. In the multivariate analysis, VEGF was 80% lower and sFlt-1 was 13.48 times higher in the group with PE. sFlt-1 concentration was higher in neonates small for gestational age (SGA) than in those appropriate for gestational age. Conclusion Higher sFlt-1 and lower VEGF levels in the group with PE, as well as higher sFlt-1 levels in SGA neonates, reflect a predominance of antiangiogenic mechanisms in PE and growth restriction.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofAmerican journal of perinatology. New York. Vol. 32, no. 12 (Oct. 2015), p. 1185-1190pt_BR
dc.rightsOpen Accessen
dc.subjectAngiogenic factorsen
dc.subjectRecém-nascido de muito baixo pesopt_BR
dc.subjectCrescimento e desenvolvimentopt_BR
dc.subjectAntiangiogenic factorsen
dc.subjectsFlt-1en
dc.subjectNutriçãopt_BR
dc.subjectNutrição da gestantept_BR
dc.subjectVEGFen
dc.subjectPrematurityen
dc.subjectPreeclampsiaen
dc.titleAngiogenic and antiangiogenic factors in preterm neonates born to mothers with and without preeclampsiapt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000978283pt_BR
dc.type.originEstrangeiropt_BR


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