Navegação Ciências Exatas e da Terra por Assunto "Nanocápsulas"
Resultados 1-12 de 12
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Degradação e estabilização do diclofenaco em nanocápsulas poliméricas
(2004) [Artigo de periódico]The parameters which affect the degradation and stabilization of diclofenac in suspensions of nanocapsules and of the corresponding spray-dried powders were investigated. Formulations were subjected to 14 months of storage ... -
Development of nanocapsule suspensions and nanocapsule spray-dried powders containing melatonin
(2006) [Artigo de periódico]Suspensões de nanocápsulas contendo melatonina foram preparadas pelo método de deposição interfacial e caracterizadas (tamanho, morfologia e eficiência de encapsulação). Foram avaliadas as influências do tipo de polímero, ... -
Effects of two types of melatonin-loaded nanocapsules with distinct supramolecular structures : Polymeric (NC) and Lipid-Core Nanocapsules (LNC) on bovine embryo culture model
(2016) [Artigo de periódico]Melatonin has been used as a supplement in culture medium to improve the efficiency of in vitro produced mammalian embryos. Through its ability to scavenge toxic oxygen derivatives and regulate cellular mRNA levels for ... -
Estabilização do ácido lipoico via encapsulação em nanocápsulas poliméricas planejadas para aplicação cutânea
(2009) [Artigo de periódico]This work reports the development of polymeric nanocapsules containing lipoic acid prepared by interfacial deposition of poli(ε-caprolactona). The suspensions showed acid pH and encapsulation efficiencies from 77 to 90%. ... -
Hydrogels containing redispersible spray-dried melatonin-loaded nanocapsules : a formulation for transdermal-controlled delivery
(2012) [Artigo de periódico]The aim of the present study was to develop a transdermal system for controlled delivery of melatonin combining three strategies: nanoencapsulation of melatonin, drying of melatonin-loaded nanocapsules, and incorporation ... -
Labeling the oily core of nanocapsules and lipid-core nanocapsules with a triglyceride conjugated to a fluorescent dye as a strategy to particle tracking in biological studies
(2014) [Artigo de periódico]The synthesis of novel fluorescent materials represents a very important step to obtain labeled nanoformulations in order to evaluate their biological behavior. The strategy of conjugating a fluorescent dye with triacylglycerol ... -
LC-MS/MS method applied to preclinical pharmacokinetic investigation of olanzapine-loaded lipid-core nanocapsules
(2014) [Artigo de periódico]In spite of different methods reported in the literature to determine olanzapine in biological fluids, all of them used high volumes of plasma. Therefore, the purpose of this paper was to develop an LC-MS/MS method using ... -
Micropartículas nanorrevestidas contendo um fármaco modelo hidrofóbico : preparação em etapa única e caracterização biofarmacêutica
(2008) [Artigo de periódico]The aim of this work was to prepare and characterize spray-dried nanocapsule-coated microparticles obtained in one step, using indomethacin as a hydrophobic drug model and poly(ε-caprolactone) or Eudragit® RS100, as polymers. ... -
Nanostructured systems containing an essential oil : protection against volatilization
(2011) [Artigo de periódico]The goal of this study was to evaluate the feasibility of preparing nanocapsules and nanoemulsions using tea tree oil as oily phase aiming to protect its volatilization. The nanostructures presented nanometric mean size ... -
Spray-drying technique to prepare innovative nanoparticulated formulations for drug administration: a brief overview
(2009) [Artigo de periódico]Polymeric nanoparticle systems (nanocapsules and nanospheres) present potential applications as drug delivery systems. Nevertheless, their full applications have not been exploited due to their limited shelf life when ... -
The antiproliferative effect of indomethacin-loaded lipid-core nanocapsules in glioma cells is mediated by cell cycle regulation, differentiation, and inhibition of survival patheways
(2013) [Artigo de periódico]Despite recent advances in radiotherapy, chemotherapy, and surgical techniques, glioblastoma multiforme (GBM) prognosis remains dismal. There is an urgent need for new therapeutic strategies. Nanoparticles of biodegradable ... -
The use of nanoencapsulation to decrease human skin irritation caused by capsaicinoids
(2014) [Artigo de periódico]Capsaicin, a topical analgesic used in the treatment of chronic pain, has irritant properties that frequently interrupt its use. In this work, the effect of nanoencapsulation of the main capsaicinoids (capsaicin and ...