Navegação Ciências Exatas e da Terra por Autor "Guterres, Silvia Stanisçuaski"
Resultados 1-20 de 30
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Arginylglycylaspartic Acid-Surface-Functionalized Doxorubicin-Loaded Lipid-Core nanocapsules as a strategy to target Alpha(V) Beta(3) integrin expressed on tumor cells
Antonow, Michelli Barcelos; Franco, Camila; Prado, Willian Andrade; Beckenkamp, Aline; Silveira, Gustavo Pozza; Buffon, Andreia; Guterres, Silvia Stanisçuaski; Pohlmann, Adriana Raffin (2018) [Artigo de periódico]Doxorubicin (Dox) clinical use is limited by dose-related cardiomyopathy, becoming more prevalent with increasing cumulative doses. Previously, we developed Dox-loaded lipid-core nanocapsules (Dox-LNC) and, in this study, ... -
Caenorhabditis elegans as an alternative in vivo model to determine oral uptake, nanotoxicity, and efficacy of melatonin-loaded lipid-core nanocapsules on paraquat damage
Charão, Mariele Feiffer; Souto, Caroline; Brucker, Natália; Barth, Anelise; Jornada, Denise Soledade; Fagundez, Daiandra de Almeida; Ávila, Daiana Silva de; Eifler-Lima, Vera Lucia; Guterres, Silvia Stanisçuaski; Pohlmann, Adriana Raffin; Garcia, Solange Cristina (2015) [Artigo de periódico]Caenorhabditis elegans is an alternative in vivo model that is being successfully used to assess the pharmacological and toxic effects of drugs. The exponential growth of nanotechnology requires the use of alternative in ... -
Caracterização e estabilidade físico-química de sistemas poliméricos nanoparticulados para administração de fármacos
Schaffazick, Scheila Rezende; Guterres, Silvia Stanisçuaski; Freitas, Liane Lucy de Lucca; Pohlmann, Adriana Raffin (2003) [Artigo de periódico]Polymeric nanoparticle systems such as nanocapsules and nanospheres present potential applications for the administration of therapeutic molecules. The physico-chemical characteristics of nanoparticle suspensions are ... -
Chitosan gel containing polymeric nanocapsules : a new formulation for vaginal drug delivery
Frank, Luiza Abrahão; Sandri, Giuseppina; D'Autilia, Francesca; Contri, Renata Vidor; Bonferoni, Maria Cristina; Caramella, Carla; Frank, Alejandro Germán; Pohlmann, Adriana Raffin; Guterres, Silvia Stanisçuaski (2014) [Artigo de periódico]The vaginal route of administration is an alternative for several treatments for either local or systemic pharmacological effects. However, the permanence of a drug in this route represents a challenge for formulation ... -
Degradação e estabilização do diclofenaco em nanocápsulas poliméricas
Muller, Claudia Regina; Haas, Sandra Elisa; Bassani, Valquiria Linck; Guterres, Silvia Stanisçuaski; Fessi, H.; Peralba, Maria do Carmo Ruaro; Pohlmann, Adriana Raffin (2004) [Artigo de periódico]The parameters which affect the degradation and stabilization of diclofenac in suspensions of nanocapsules and of the corresponding spray-dried powders were investigated. Formulations were subjected to 14 months of storage ... -
Development and physicochemical characterization of dexamethasone-loaded polymeric nanocapsule suspensions
Friedrich, Rossana Barcellos; Fontana, Márcia Camponogara; Beck, Ruy Carlos Ruver; Pohlmann, Adriana Raffin; Guterres, Silvia Stanisçuaski (2008) [Artigo de periódico]The influence of drug concentration, oil phase, and surfactants on the characteristics of dexamethasone-loaded nanocapsules was investigated. The best formulations were obtained at dexamethasone concentrations of 0.25 and ... -
Development of nanocapsule suspensions and nanocapsule spray-dried powders containing melatonin
Schaffazick, Scheila Rezende; Pohlmann, Adriana Raffin; Mezzalira, Graziela; Guterres, Silvia Stanisçuaski (2006) [Artigo de periódico]Suspensões de nanocápsulas contendo melatonina foram preparadas pelo método de deposição interfacial e caracterizadas (tamanho, morfologia e eficiência de encapsulação). Foram avaliadas as influências do tipo de polímero, ... -
Effects of two types of melatonin-loaded nanocapsules with distinct supramolecular structures : Polymeric (NC) and Lipid-Core Nanocapsules (LNC) on bovine embryo culture model
Komninou, Eliza Rossi; Remião, Mariana Härter; Lucas, Caroline Gomes; Domingues, William Borges; Basso, Andréa Cristina; Jornada, Denise Soledade; Deschamps, João Carlos; Beck, Ruy Carlos Ruver; Pohlmann, Adriana Raffin; Bordignon, Vilceu; Seixas, Fabiana Kömmling; Campos, Vinicius Farias; Guterres, Silvia Stanisçuaski; Collares, Tiago Veiras (2016) [Artigo de periódico]Melatonin has been used as a supplement in culture medium to improve the efficiency of in vitro produced mammalian embryos. Through its ability to scavenge toxic oxygen derivatives and regulate cellular mRNA levels for ... -
Estabilização do ácido lipoico via encapsulação em nanocápsulas poliméricas planejadas para aplicação cutânea
Külkamp-Guerreiro, Irene Clemes; Paese, Karina; Guterres, Silvia Stanisçuaski; Pohlmann, Adriana Raffin (2009) [Artigo de periódico]This work reports the development of polymeric nanocapsules containing lipoic acid prepared by interfacial deposition of poli(ε-caprolactona). The suspensions showed acid pH and encapsulation efficiencies from 77 to 90%. ... -
Evaluation of lipoic acid topical application on rats skin wound healing
Külkamp-Guerreiro, Irene Clemes; Souza, Marielly Nunes; Bianchin, Mariana Domingues; Isoppo, Mateus; Freitas, Joana Sachetti; Alves, João Alex; Piovezan, Anna Paula; Pohlmann, Adriana Raffin; Guterres, Silvia Stanisçuaski (2013) [Artigo de periódico]PURPOSE: To evaluate the effects of lipoic acid (thioctic acid) topical application on wound healing on rats skin, and the consequences of lipoic acid nanoencapsulation on this process. METHODS: The model used was the ... -
Hydrogels containing redispersible spray-dried melatonin-loaded nanocapsules : a formulation for transdermal-controlled delivery
Hoffmeister, Cristiane Rodrigues Drago; Durli, Taís Lusa; Schaffazick, Scheila Rezende; Raffin, Renata Platcheck; Bender, Eduardo André; Beck, Ruy Carlos Ruver; Pohlmann, Adriana Raffin; Guterres, Silvia Stanisçuaski (2012) [Artigo de periódico]The aim of the present study was to develop a transdermal system for controlled delivery of melatonin combining three strategies: nanoencapsulation of melatonin, drying of melatonin-loaded nanocapsules, and incorporation ... -
Impactos da nanotecnologia na saúde : produção de medicamentos
Dimer, Frantiescoli Anversa; Friedrich, Rossana Barcellos; Beck, Ruy Carlos Ruver; Guterres, Silvia Stanisçuaski; Pohlmann, Adriana Raffin (2013) [Artigo de periódico]Several studies have described the benefits of nanoscience and nanotechnology (N&N) in different sectors such as agriculture, energy, environmental preservation, and public health. The rapid evolution of N&N can be shown ... -
Ionic liquid-loaded microcapsules doped into dental resin infiltrants
Cuppini, Marla; Garcia, Isadora Martini; Souza, Virgínia Serra de; Zatta, Kelly Cristine; Visioli, Fernanda; Leitune, Vicente Castelo Branco; Guterres, Silvia Stanisçuaski; Scholten, Jackson Damiani; Collares, Fabrício Mezzomo (2021) [Artigo de periódico]Resin infiltrants have been effectively applied in dentistry to manage non-cavitated carious lesions in proximal dental surfaces. However, the common formulations are composed of inert methacrylate monomers. In this study, ... -
Labeling the oily core of nanocapsules and lipid-core nanocapsules with a triglyceride conjugated to a fluorescent dye as a strategy to particle tracking in biological studies
Fiel, Luana Almeida; Contri, Renata Vidor; Bica, Juliane Freitas; Figueiró, Fabrício; Battastini, Ana Maria Oliveira; Guterres, Silvia Stanisçuaski; Pohlmann, Adriana Raffin (2014) [Artigo de periódico]The synthesis of novel fluorescent materials represents a very important step to obtain labeled nanoformulations in order to evaluate their biological behavior. The strategy of conjugating a fluorescent dye with triacylglycerol ... -
LC-MS/MS method applied to preclinical pharmacokinetic investigation of olanzapine-loaded lipid-core nanocapsules
Dimer, Frantiescoli Anversa; Pigatto, Maiara Cássia; Pohlmann, Adriana Raffin; Dalla Costa, Teresa Cristina Tavares; Guterres, Silvia Stanisçuaski (2014) [Artigo de periódico]In spite of different methods reported in the literature to determine olanzapine in biological fluids, all of them used high volumes of plasma. Therefore, the purpose of this paper was to develop an LC-MS/MS method using ... -
Lipid-core nanocapsules : mechanism of self-assembly, control of size and loading capacity
Jornada, Denise Soledade; Fiel, Luana Almeida; Condotta, Kelly Bueno; Gerent, Josepe Franco; Petzhold, Cesar Liberato; Beck, Ruy Carlos Ruver; Guterres, Silvia Stanisçuaski; Pohlmann, Adriana Raffin (2012) [Artigo de periódico]Nanotechnology in pharmaceutics has the potential to improve drug efficacy by influencing drug distribution in tissues. Nanocarriers have been developed as drug delivery systems to be administered by different biological ... -
Methotrexate diethyl ester-loaded lipid-core nanocapsules in aqueous solution increased antineoplastic effects in resistant breast cancer cell line
Yurgel, Virgina Campello; Oliveira, Catiúscia Padilha de; Begnini, Karine Rech; Schultze, Eduarda; Thurow, Helena Strelow; Leon, Priscila Marques Moura de; Dellagostin, Odir Antônio; Campos, Vinicius Farias; Beck, Ruy Carlos Ruver; Guterres, Silvia Stanisçuaski; Collares, Tiago Veiras; Pohlmann, Adriana Raffin; Seixas, Fabiana Kömmling (2014) [Artigo de periódico]Breast cancer is the most frequent cancer affecting women. Methotrexate (MTX) is an antimetabolic drug that remains important in the treatment of breast cancer. Its efficacy is compromised by resistance in cancer cells ... -
Methotrexate-loaded lipid-core nanocapsules are highly effective in the control of inflammation in synovial cells and a chronic arthritis model
Boechat, Antonio Luiz; Oliveira, Catiúscia Padilha de; Tarragô, Andrea Monteiro; Costa, Allyson Guimarães da; Malheiro, Adriana; Guterres, Silvia Stanisçuaski; Pohlmann, Adriana Raffin (2015) [Artigo de periódico]Background: Rheumatoid arthritis (RA) is the most common autoimmune disease in the word, affecting 1% of the population. Long-term prognosis in RA was greatly improved following the introduction of highly effective medications ... -
Micropartículas nanorrevestidas contendo um fármaco modelo hidrofóbico : preparação em etapa única e caracterização biofarmacêutica
Domingues, Gislane Scholze; Guterres, Silvia Stanisçuaski; Beck, Ruy Carlos Ruver; Pohlmann, Adriana Raffin (2008) [Artigo de periódico]The aim of this work was to prepare and characterize spray-dried nanocapsule-coated microparticles obtained in one step, using indomethacin as a hydrophobic drug model and poly(ε-caprolactone) or Eudragit® RS100, as polymers. ... -
Nanoparticle-coated organic-inorganic microparticles : experimental design and gastrointestinal tolerance evaluation
Beck, Ruy Carlos Ruver; Haas, Sandra Elisa; Guterres, Silvia Stanisçuaski; Ré, Maria Inês; Benvenutti, Edilson Valmir; Pohlmann, Adriana Raffin (2006) [Artigo de periódico]The influences of the spray-drying parameters and the type of nanoparticles (nanocapsules or nanospheres) on the characteristics of nanoparticle-coated diclofenac-loaded microparticles were investigated by using a factorial ...