Browsing Health Sciences by Author "Fachel, Flávia Nathiely Silveira"
Now showing items 1-7 of 7
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Achyrocline satureioides (Lam.) DC (Asteraceae) extract-loaded nanoemulsions as a promising topical wound Healing delivery system : in vitro assessments in human keratinocytes (HaCaT) and HET-CAM irritant potential
Balestrin, Lucélia Albarello; Kreutz, Tainá; Fachel, Flávia Nathiely Silveira; Bidone, Juliana; Gelsleichter, Nicolly Espindola; Koester, Leticia Scherer; Bassani, Valquiria Linck; Braganhol, Elizandra; Dora, Cristiana Lima; Teixeira, Helder Ferreira (2021) [Journal article]Achyrocline satureioides (Lam.) DC Asteraceae extracts (ASEs) have been investigated for the treatment of various skin disorders. This study reports the effects of ASE-loaded nanoemulsions (NEASE) on the cellular viability, ... -
Compatibility study of rosmarinic acid with excipients used in pharmaceutical solid dosage forms using thermal and non-thermal techniques
Veras, Kleyton Santos; Fachel, Flávia Nathiely Silveira; Pittol, Vanessa; Garcia, Keth Ribeiro; Bassani, Valquiria Linck; Santos, Venina dos; Henriques, Amelia Teresinha; Teixeira, Helder Ferreira; Koester, Leticia Scherer (2019) [Journal article]Rosmarinic acid (RA) is a phenolic compound that presents well-documented anti-inflammatory, antioxidant and antitumor activities, and based on its pharmacological potential and poor bioavailability, several solid dosage ... -
Curcumin and quercetin-loaded lipid nanocarriers : development of omega-3 mucoadhesive nanoemulsions for intranasal administration
Vaz, Gustavo Richter; Falkembach, Mariana Corrêa; Batista, Matheus Monteiro; Barros, Paula Alice Bezerra; Oliveira, Meliza da Conceição; Baisch, Ana Luiza Muccillo; Yurgel, Virgina Campello; Buttini, Francesca; Soares, Felix Alexandre Antunes; Cordeiro, Larissa Marafiga; Fachel, Flávia Nathiely Silveira; Teixeira, Helder Ferreira; Bidone, Juliana; Oliveira, Patrícia Diaz de; Sonvico, Fabio; Dora, Cristiana Lima (2022) [Journal article]Curcumin (CUR) and quercetin (QU) are potential compounds for treatment of brain diseases such as neurodegenerative diseases (ND) because of their anti-inflammatory and antioxidant properties. However, low water solubility ... -
Cyclodextrin-based delivery systems and hydroxycinnamic acids : interactions and effects on crucial parameters influencing oral bioavailability — aReview
Veras, Kleyton Santos; Fachel, Flávia Nathiely Silveira; Bassani, Valquiria Linck; Teixeira, Helder Ferreira; Koester, Leticia Scherer (2022) [Journal article]Hydroxycinnamic acids (HCAs) are a subclass of phenolic acids presenting caffeic acid (CA), chlorogenic acid (CGA), coumaric acid (COA) isomers, ferulic acid (FA), and rosmarinic acid (RA) as the major representants, being ... -
Effect of hydrogel containing Achyrocline satureioides (Asteraceae) extract–loaded nanoemulsions on wound healing activity
Balestrin, Lucélia Albarello; Back, Patrícia Inês; Marques, Magno da Silva; Araújo, Gabriela de Moraes Soares; Falkembach, Mariana Corrêa; Batista, Matheus Monteiro; Silveira, Tony Leandro Rezende da; Rodrigues, Jamile Lima; Fachel, Flávia Nathiely Silveira; Koester, Leticia Scherer; Bassani, Valquiria Linck; Horn, Ana Paula; Dora, Cristiana Lima; Teixeira, Helder Ferreira (2022) [Journal article]Achyrocline satureioides (Lam.) DC extract–loaded nanoemulsions have demonstrated potential for wound healing, with promising effects on keratinocyte proliferation. We carried out the first in vivo investigation of the ... -
Oral pharmacokinetics of hydroxycinnamic acids : an updated review
Veras, Kleyton Santos; Fachel, Flávia Nathiely Silveira; Araújo, Bibiana Verlindo de; Teixeira, Helder Ferreira; Koester, Leticia Scherer (2022) [Journal article]Hydroxycinnamic acids (HCAs) such as caffeic acid (CA), chlorogenic acid (CGA), coumaric acid (COA) isomers, ferulic acid (FA) and rosmarinic acid (RA) are natural phenolic acids with widespread distribution in vegetal ... -
Sensitive ultra-fast liquid chromatography method for rosmarinic acid determination in Wistar rat’s plasma and brain
Fachel, Flávia Nathiely Silveira; Michels, Luana Roberta; Azambuja, Juliana Hofstätter; Bassani, Valquiria Linck; Koester, Leticia Scherer; Henriques, Amelia Teresinha; Braganhol, Elizandra; Teixeira, Helder Ferreira (2019) [Journal article]Rosmarinic acid (RA) is a polyphenolic compound recently associated to a neuroprotective potential. Nevertheless, besides the RA poor bioavailability and availability in the central nervous system (CNS) some alternatives ...