Listar Ciencias Biologicas por autor "Jaeger, Mariane da Cunha"

Mostrando ítems 1-4 de 4

    • Antitumor activities and cellular changes induced by TrkB inhibition in medulloblastoma 

      Thomaz, Amanda Cristina Godot; Pinheiro, Kelly de Vargas; Souza, Bárbara Kunzler; Gregianin, Lauro José; Brunetto, Algemir Lunardi; Brunetto, Andre Tessainer; Farias, Caroline Brunetto de; Jaeger, Mariane da Cunha; Ramaswamy, Vijay; Nor, Carolina; Taylor, Michael David; Roesler, Rafael (2019) [Artículo de periódico]
      Neurotrophins are critically involved in regulating normal neural development and plasticity. Brain-derived neurotrophic factor (BDNF), a neurotrophin that acts by binding to the tropomyosin receptor kinase B (TrkB) receptor, ...

    • EHMT2/G9a as an epigenetic target in pediatric and adult brain tumors 

      Souza, Bárbara Kunzler; Freire, Natália Hogetop; Jaeger, Mariane da Cunha; Farias, Caroline Brunetto de; Brunetto, Algemir Lunardi; Brunetto, Andre Tessainer; Roesler, Rafael (2021) [Artículo de periódico]
      Epigenetic mechanisms, including post-translational modifications of DNA and histones that influence chromatin structure, regulate gene expression during normal development and are also involved in carcinogenesis and cancer ...

    • Primary cells derived from Tuberous Sclerosis Complex patients show autophagy alteration in the haploinsufficiency state 

      Rosset, Clévia; Jaeger, Mariane da Cunha; Chiela, Eduardo Cremonese Filippi; Reis, Larissa Brussa; Sartor, Ivaine Tais Sauthier; Netto, Cristina Brinckmann Oliveira; Farias, Caroline Brunetto de; Roesler, Rafael; Prolla, Patrícia Ashton (2021) [Artículo de periódico]
      Tuberous sclerosis complex (TSC) is an autosomal dominant cancer predisposition disorder caused by heterozygous mutations in TSC1 or TSC2 genes and characterized by mTORC1 hyperactivation. TSC-associated tumors develop ...

    • Reverse engineering of Ewing Sarcoma regulatory network uncovers PAX7 and RUNX3 as master regulators associated with good prognosis 

      Dantas, Marcel da Câmara Ribeiro; Imparato, Danilo Oliveira; Dalmolin, Matheus Gibeke Siqueira; Farias, Caroline Brunetto de; Brunetto, Andre Tessainer; Jaeger, Mariane da Cunha; Roesler, Rafael; Sinigaglia, Marialva; Dalmolin, Rodrigo Juliani Siqueira (2021) [Artículo de periódico]
      Ewing Sarcoma (ES) is a rare malignant tumor occurring most frequently in adolescents and young adults. The ES hallmark is a chromosomal translocation between the chromosomes 11 and 22 that results in an aberrant transcription ...