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dc.contributor.authorTeixeira, Rayane Brinckpt_BR
dc.contributor.authorBarboza, Tatiana Evelynpt_BR
dc.contributor.authorAraújo, Carla Cristina dept_BR
dc.contributor.authorSiqueira, Rafaelapt_BR
dc.contributor.authorCastro, Alexandre Luz dept_BR
dc.contributor.authorBonetto, Jéssica Hellen Polettopt_BR
dc.contributor.authorSeolin, Bruna Gazzi de Limapt_BR
dc.contributor.authorCarraro, Cristina Campospt_BR
dc.contributor.authorBelló-Klein, Adrianept_BR
dc.contributor.authorSingal, Pawan K.pt_BR
dc.contributor.authorAraújo, Alex Sander da Rosapt_BR
dc.date.accessioned2019-02-02T02:31:33Zpt_BR
dc.date.issued2018pt_BR
dc.identifier.issn0973-7138pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/188512pt_BR
dc.description.abstractHyperthyroidism can lead to the activation of proteins which are associated with inflammation, apoptosis, hypertrophy, and heart failure. This study aimed to explore the inflammatory and apoptotic proteins involved in the hyperthyroidism-induced cardiac hypertrophy establishment. Male Wistar rats were divided into control and hyperthyroid (12 mg/L L-thyroxine, in drinking water for 28 days) groups. The expression of inflammatory and apoptotic signaling proteins was quantified in the left ventricle by Western blot. Hyperthyroidism was confirmed by evaluation of T3 and T4 levels, as well as cardiac hypertrophy development. There was no change in the expression of HSP70, HIF1-a, TNF-a, MyD88, p-NFjB, NFjB, p-p38, and p38. Reduced expression of p53 and PGC1-a was associated with increased TLR4 and decreased IL-10 expression. Decreased Bcl-2 expression and increased Bax/Bcl-2 ratio were also observed. The results suggest that reduced PGC1-a and IL-10, and elevated TLR4 proteins expression could be involved with the diminished mitochondrial biogenesis and anti-inflammatory response, as well as cell death signaling, in the establishment of hyperthyroidism-induced maladaptive cardiac hypertrophy.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofJournal of biosciences. [Bangalore]. Vol. 43, no. 5 (Dec. 2018), p. 887–895pt_BR
dc.rightsOpen Accessen
dc.subjectHipertireoidismopt_BR
dc.subjectCardiac hypertrophyen
dc.subjectCardiomegaliapt_BR
dc.subjectCell deathen
dc.subjectHyperthyroidismen
dc.subjectMorte celularpt_BR
dc.subjectInflamaçãopt_BR
dc.subjectInflammationen
dc.subjectPGC1-aen
dc.titleDecreased PGC1-α levels and increased apoptotic protein signaling are associated with the maladaptive cardiac hypertrophy in hyperthyroidismpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001083242pt_BR
dc.type.originEstrangeiropt_BR


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