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dc.contributor.authorCalcagnotto, Maria Elisapt_BR
dc.date.accessioned2018-10-09T02:34:02Zpt_BR
dc.date.issued2016pt_BR
dc.identifier.issn1664-0640pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/183216pt_BR
dc.description.abstractInhibitory circuits play an important role in synaptic plasticity during development and adulthood. Changes in interneuronal activity induce structural and synaptic rearrangements of inhibitory interneurons, network oscillations, and homeostatic plasticity. In addition to epileptic seizures, deficits in the inhibitory system lead to aberrant information processing and cognitive impairment in various neurological disorders. Studies exploring the structural and functional plasticity of interneurons are essential, not only to understand the mechanisms underlying normal development and behavior but also, to identify the etiology of different psychiatric and neurological disorders to pursue new therapies. Here, it will be discussed the role of inhibitory circuit in the synaptic plasticity, and how cellular replacement strategies can remodel changes in circuit function and homeostasis in the context of brain repair.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofFrontiers in psychiatry. Lausanne. Vol. 7 (May 2016), 86, 4 p.pt_BR
dc.rightsOpen Accessen
dc.subjectGABAen
dc.subjectÁcido gama-aminobutíricopt_BR
dc.subjectInterneurôniospt_BR
dc.subjectInterneuronsen
dc.subjectPlasticidade neuronalpt_BR
dc.subjectSynaptic plasticityen
dc.subjectBrain oscillationsen
dc.subjectCell replacementen
dc.titleInterneurons : role in maintaining and restoring synaptic plasticitypt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001076720pt_BR
dc.type.originEstrangeiropt_BR


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