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dc.contributor.authorSalgueiro, Andréia Caroline Fernandespt_BR
dc.contributor.authorFolmer, Vanderleipt_BR
dc.contributor.authorSilva, Marianne Pires dapt_BR
dc.contributor.authorMendez, Andreas Sebastian Loureiropt_BR
dc.contributor.authorZemolin, Ana Paula Pegoraropt_BR
dc.contributor.authorPosser, Thaíspt_BR
dc.contributor.authorFranco, Jeferson Luispt_BR
dc.contributor.authorPuntel, Robson Luizpt_BR
dc.contributor.authorPuntel, Gustavo Orionept_BR
dc.date.accessioned2018-09-26T02:33:49Zpt_BR
dc.date.issued2015pt_BR
dc.identifier.issn1942-0994pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/182698pt_BR
dc.description.abstractThis study was designed to evaluate the effects of Bauhinia forficata Link subsp. pruinosa (BF) tea on oxidative stress and liver damage in streptozotocin (STZ)-induced diabetic mice. Diabetic male mice have remained 30 days without any treatment. BF treatment started on day 31 and continued for 21 days as a drinking-water substitute.We evaluated (1) BF chemical composition; (2) glucose levels; (3) liver/bodyweight ratio and liver transaminases; (4) reactive oxygen species (ROS), lipid peroxidation, and protein carbonylation in liver; (5) superoxide dismutase (SOD) and catalase (CAT) activities in liver; (6) 𝛿-aminolevulinate dehydratase (𝛿-ALA-D) and nonprotein thiols (NPSH) in liver; (7) Nrf2, NQO-1, and HSP70 levels in liver and pancreas. Phytochemical analyses identified four phenols compounds. Diabetic mice present high levels of NQO-1 in pancreas, increased levels of ROS and lipid peroxidation in liver, and decrease in CAT activity. BF treatment normalized all these parameters. BF did not normalize hyperglycemia, liver/body weight ratio, aspartate aminotransferase, protein carbonyl, NPSH levels, and 𝛿-ALA-D activity. The raised oxidative stress seems to be a potential mechanism involved in liver damage in hyperglycemic conditions. Our results indicated that BF protective effect could be attributed to its antioxidant capacity, more than a hypoglycemic potential.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofOxidative Medicine and Cellular Longevity. New York. Vol. 2016, Article ID 8902954, p. 1-9pt_BR
dc.rightsOpen Accessen
dc.subjectFarmáciapt_BR
dc.titleEffects of Bauhinia forficata tea on oxidative stress and liver damage in diabetic micept_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000993952pt_BR
dc.type.originEstrangeiropt_BR


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