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dc.contributor.authorPedrini, Jose Luispt_BR
dc.contributor.authorPedrini, Mariana Guedespt_BR
dc.contributor.authorSavaris, Ricardo Francalaccipt_BR
dc.contributor.authorMachado, Lucianapt_BR
dc.contributor.authorGrudzinski, Melinapt_BR
dc.contributor.authorZettler, Claudio Galleanopt_BR
dc.date.accessioned2018-09-19T02:32:49Zpt_BR
dc.date.issued2004pt_BR
dc.identifier.issn1234-1010pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/182169pt_BR
dc.description.abstractIt is believed that a local recurrence of a primitive breast cancer has the same prognostic factor profi le as its primary breast cancer tumor. Material/Methods: We compared the immunohistochemical expressions of the tumor suppressor protein p53, estrogen receptor (ER), c-erbB2, and E-cadherin in 57 primary invasive breast cancers and in their respective LRs. The McNemar test and the kappa index were used for statistical analysis. Results: In 30 patients (52.6%) the expression of at least one of these markers was different between the primary and locally recurrent tumors. No signifi cant difference was observed between variations in the positive and negative expressions in the primary tumor and local recurrence in cerbB2 (kappa= 0.86), E-cadherin (kappa=0.55), and p53 (kappa=0.7). However, the ER presented a low kappa index (kappa=0.26, p>0.05). Conclusions: ER expression should be reviewed in local recurrent breast cancer. This relevant change in ER expression is likely to change the current clinical practice in breast cancer evaluation and treatment.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofMedical science monitor. Warsaw. Vol. 10, n. 12 (2004), p. BR462-467pt_BR
dc.rightsOpen Accessen
dc.subjectbreast canceren
dc.subjectNeoplasias da mamapt_BR
dc.subjectp53en
dc.subjectRecidiva local de neoplasiapt_BR
dc.subjectc-erbB2en
dc.subjectReceptores estrogenicospt_BR
dc.subjectE-cadherinen
dc.subjectIdoso de 80 anos ou maispt_BR
dc.subjectMeia-idadept_BR
dc.subjectestrogen receptoren
dc.subjectlocal recurrenceen
dc.titleReassessing tumor markers in local recurrences of breast cancer : a new insightpt_BR
dc.title.alternativeReassessing tumor markers in local recurrences of breast cancer: a new insighten
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001076561pt_BR
dc.type.originEstrangeiropt_BR


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