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dc.contributor.authorBahia, Luciana Ribeiropt_BR
dc.contributor.authorRosa, Roger dos Santospt_BR
dc.contributor.authorSantos Filho, Raul Dias dospt_BR
dc.contributor.authorAraújo, Denizar Viannapt_BR
dc.date.accessioned2018-09-19T02:32:39Zpt_BR
dc.date.issued2018pt_BR
dc.identifier.issn2359-4292pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/182153pt_BR
dc.description.abstractCardiovascular diseases are the leading cause of death in Brazil, imposing substantial economic burden on the health care system. Familial hypercholesterolemia (FH) is known to greatly increase the risk of premature coronary artery disease (CAD). This study aimed to estimate the economic impact of hospitalizations due to CAD attributable to FH in the Brazilian Unified Health Care System (SUS). Subjects and methods: Retrospective, cross-sectional study of data obtained from the Hospital Information System of the SUS (SIHSUS). We selected all adults (≥ 20 years of age) hospitalized from 2012- 2014 with primary diagnoses related to CAD (ICD-10 I20 to I25). Attributable risk methodology estimated the contribution of FH in the outcomes of interest, using international data for prevalence (0.4% and 0.73%) and relative risk for events (RR = 8.56). Results: Assuming an international prevalence of FH of 0.4% and 0.73%, of the 245,981 CAD admissions/year in Brazil, approximately 7,249 and 12,915, respectively, would be attributable to an underlying diagnosis of FH. The total cost due to CAD per year, considering both sexes and all adults, was R$ 985,919,064, of which R$ 29,053,500 and R$ 51,764,175, respectively, were estimated to be attributable to FH. The average cost per FH-related CAD event was R$ 4,008. Conclusion: Based on estimated costs of hospitalization for CAD, we estimated that 2.9-5.3% are directed to FH patients. FH can require early specific therapies to lower risk in families. It is mandatory to determine the prevalence of FH and institute appropriate treatment to minimize the clinical and economic impact of this disease in Brazil.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofArchives of endocrinology and metabolism. São Paulo. Vol. 62, no. 3 (May/June 2018), p. 303-308.pt_BR
dc.rightsOpen Accessen
dc.subjectCosts and cost analysisen
dc.subjectDoença da artéria coronarianapt_BR
dc.subjectHospitalizaçãopt_BR
dc.subjectcoronary artery diseaseen
dc.subjectFamilial hypercholesterolemiaen
dc.subjectCustos e análise de custopt_BR
dc.subjectSistema Único de Saúdept_BR
dc.subjectBrazilen
dc.subjectBrasilpt_BR
dc.subjectHospitalizationen
dc.titleEstimated costs of hospitalization due to coronary artery disease attributable to familial hypercholesterolemia in the Brazilian public health systempt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001073274pt_BR
dc.type.originNacionalpt_BR


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