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dc.contributor.authorTeixeira, Antônio Lúciopt_BR
dc.contributor.authorGama, Clarissa Severinopt_BR
dc.contributor.authorRocha, Natalia Pessoapt_BR
dc.contributor.authorTeixeira, Mauro Martinspt_BR
dc.date.accessioned2018-09-18T02:30:01Zpt_BR
dc.date.issued2018pt_BR
dc.identifier.issn1664-0640pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/182092pt_BR
dc.description.abstractEotaxin-1/CCL11 is a chemokine originally implicated in the selective recruitment of eosinophils into inflammatory sites during allergic reactions, being thoroughly investigated in asthma, allergic rhinitis, and other eosinophil-related conditions. Eotaxin-1/CCL11 is also involved with a skewed immune response toward a type-2 (Th2) profile. In addition to its role in immune response, recent studies have shown that eotaxin-1/CCL11 is associated with aging, neurogenesis and neurodegeneration, being able to influence neural progenitor cells, and microglia. Increased circulating levels of eotaxin-1/CCL11 have been described in major psychiatric disorders (schizophrenia, bipolar disorder, major depression), sometimes correlating with the severity of psychopathological and cognitive parameters. As similar findings have been reported in neurodegenerative conditions such as Alzheimer’s disease, it has been hypothesized that mechanisms involving eotaxin-1/CCL11 signaling may underlie the “accelerated aging” profile commonly linked to psychiatric disorders. Future studies must determine whether eotaxin-1/CCL11 can be regarded as a prognostic biomarker and/or as therapeutic target for resistant/progressive cases.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofFrontiers in psychiatry. Lausanne. Vol. 9 (June 2018), 241, 6 p.pt_BR
dc.rightsOpen Accessen
dc.subjectEotaxin-1en
dc.subjectEsquizofreniapt_BR
dc.subjectCCL11en
dc.subjectTranstorno bipolarpt_BR
dc.subjectschizophreniaen
dc.subjectEnvelhecimentopt_BR
dc.subjectbipolar disorderen
dc.subjectDoença de Alzheimerpt_BR
dc.subjectQuimiocina CCL11pt_BR
dc.subjectdepressionen
dc.subjectagingen
dc.subjectAlzheimer’s diseaseen
dc.titleRevisiting the role of eotaxin-1/CCL11 in psychiatric disorderspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001073428pt_BR
dc.type.originEstrangeiropt_BR


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