Biological differences between melancholic and nonmelancholic depression subtyped by the CORE measure
dc.contributor.author | Spanemberg, Lucas | pt_BR |
dc.contributor.author | Caldieraro, Marco Antonio Knob | pt_BR |
dc.contributor.author | Vares, Edgar Arrua | pt_BR |
dc.contributor.author | Aguiar, Bianca Wollenhaupt de | pt_BR |
dc.contributor.author | Kauer-Sant'Anna, Márcia | pt_BR |
dc.contributor.author | Kawamoto, Sheila Yuri | pt_BR |
dc.contributor.author | Galvão, Emily | pt_BR |
dc.contributor.author | Parker, Gordon | pt_BR |
dc.contributor.author | Fleck, Marcelo Pio de Almeida | pt_BR |
dc.date.accessioned | 2018-08-28T02:29:22Z | pt_BR |
dc.date.issued | 2014 | pt_BR |
dc.identifier.issn | 1178-2021 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/181496 | pt_BR |
dc.description.abstract | Background: The purpose of this study was to compare melancholic patients rated by the CORE measure of observable psychomotor disturbance with nonmelancholic and control subjects across a set of biomarkers. Methods: Depressed patients were classified as melancholic or nonmelancholic by using the CORE measure. Both groups of patients, as well as control subjects, were compared for a set of clinical and laboratory measures. Serum levels of brain-derived neurotrophic factor, of two markers of oxidative stress (protein carbonyl content [PCC] and thiobarbituric acid reactive substances [TBARS]), and of several immunity markers (interleukin [IL]-2, IL-4, IL-6, IL-10, IL-17, tumor necrosis factor-alpha, and interferon-gamma) were analyzed. Results: Thirty-three depressed patients and 54 healthy controls were studied. Depressive patients showed higher IL-4, IL-6, and PCC values than healthy controls. Thirteen (39%) of the depressed patients were assigned as melancholic by the CORE measure. They generated lower interferon-gamma (compared with nonmelancholic depressed patients) and TBARS (compared with both the nonmelancholic subset and controls) and returned higher IL-6 levels than controls. Both depressive groups generated higher PCC scores than controls, with no difference between melancholic and nonmelancholic subsets. Conclusion: A sign-based measure to rate melancholia was able to replicate and extend biological findings discriminating melancholic depression. Signs of psychomotor disturbance may be a useful diagnostic measure of melancholia. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Neuropsychiatric disease and treatment. Auckland. Vol. 10 (2014), p. 1523-1531 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Depressão | pt_BR |
dc.subject | Brain-derived neurotrophic factor | en |
dc.subject | Melancholic depression | en |
dc.subject | Estresse oxidativo | pt_BR |
dc.subject | Inflammatory cytokines | en |
dc.subject | Citocinas | pt_BR |
dc.subject | Fator neurotrófico derivado do encéfalo | pt_BR |
dc.subject | Oxidative stress | en |
dc.title | Biological differences between melancholic and nonmelancholic depression subtyped by the CORE measure | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000964772 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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