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dc.contributor.authorSpanemberg, Lucaspt_BR
dc.contributor.authorCaldieraro, Marco Antonio Knobpt_BR
dc.contributor.authorVares, Edgar Arruapt_BR
dc.contributor.authorAguiar, Bianca Wollenhaupt dept_BR
dc.contributor.authorSant’Anna, Marcia Kauerpt_BR
dc.contributor.authorKawamoto, Sheila Yuript_BR
dc.contributor.authorGalvão, Emilypt_BR
dc.contributor.authorParker, Gordonpt_BR
dc.contributor.authorFleck, Marcelo Pio de Almeidapt_BR
dc.date.accessioned2018-08-28T02:29:22Zpt_BR
dc.date.issued2014pt_BR
dc.identifier.issn1178-2021pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/181496pt_BR
dc.description.abstractBackground: The purpose of this study was to compare melancholic patients rated by the CORE measure of observable psychomotor disturbance with nonmelancholic and control subjects across a set of biomarkers. Methods: Depressed patients were classified as melancholic or nonmelancholic by using the CORE measure. Both groups of patients, as well as control subjects, were compared for a set of clinical and laboratory measures. Serum levels of brain-derived neurotrophic factor, of two markers of oxidative stress (protein carbonyl content [PCC] and thiobarbituric acid reactive substances [TBARS]), and of several immunity markers (interleukin [IL]-2, IL-4, IL-6, IL-10, IL-17, tumor necrosis factor-alpha, and interferon-gamma) were analyzed. Results: Thirty-three depressed patients and 54 healthy controls were studied. Depressive patients showed higher IL-4, IL-6, and PCC values than healthy controls. Thirteen (39%) of the depressed patients were assigned as melancholic by the CORE measure. They generated lower interferon-gamma (compared with nonmelancholic depressed patients) and TBARS (compared with both the nonmelancholic subset and controls) and returned higher IL-6 levels than controls. Both depressive groups generated higher PCC scores than controls, with no difference between melancholic and nonmelancholic subsets. Conclusion: A sign-based measure to rate melancholia was able to replicate and extend biological findings discriminating melancholic depression. Signs of psychomotor disturbance may be a useful diagnostic measure of melancholia.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofNeuropsychiatric disease and treatment. Auckland. Vol. 10 (2014), p. 1523-1531pt_BR
dc.rightsOpen Accessen
dc.subjectDepressãopt_BR
dc.subjectBrain-derived neurotrophic factoren
dc.subjectEstresse oxidativopt_BR
dc.subjectMelancholic depressionen
dc.subjectInflammatory cytokinesen
dc.subjectCitocinaspt_BR
dc.subjectOxidative stressen
dc.subjectFator neurotrófico derivado do encéfalopt_BR
dc.titleBiological differences between melancholic and nonmelancholic depression subtyped by the CORE measurept_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000964772pt_BR
dc.type.originEstrangeiropt_BR


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