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dc.contributor.authorBeber, Ana Rubia Costapt_BR
dc.contributor.authorPolina, Evelise Reginapt_BR
dc.contributor.authorBiolo, Andreiapt_BR
dc.contributor.authorSantos, Bruna L.pt_BR
dc.contributor.authorGomes, Daiane do Carmopt_BR
dc.contributor.authorLa Porta, Vanessa Laubertpt_BR
dc.contributor.authorOlsen, Virgílio da Rochapt_BR
dc.contributor.authorClausell, Nadine Oliveirapt_BR
dc.contributor.authorRohde, Luis Eduardo Paimpt_BR
dc.contributor.authorSantos, Kátia Gonçalves dospt_BR
dc.date.accessioned2018-07-31T02:33:18Zpt_BR
dc.date.issued2016pt_BR
dc.identifier.issn1932-6203pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/180807pt_BR
dc.description.abstractCirculating levels of matrix metalloproteinase-2 (MMP-2) predict mortality and hospital admission in heart failure (HF) patients. However, the role of MMP-2 gene polymorphisms in the susceptibility and prognosis of HF remains elusive. In this study, 308 HF outpatients (216 Caucasian- and 92 African-Brazilians) and 333 healthy subjects (256 Caucasian- and 77 African- Brazilians) were genotyped for the -1575G>A (rs243866), -1059G>A (rs17859821), and -790G>T (rs243864) polymorphisms in the MMP-2 gene. Polymorphisms were analyzed individually and in combination (haplotype), and positive associations were adjusted for clinical covariates. Although allele frequencies were similar in HF patients and controls in both ethnic groups, homozygotes for the minor alleles were not found among African-Brazilian patients. After a median follow-up of 5.3 years, 124 patients (40.3%) died (54.8%of them for HF). In Caucasian-Brazilians, the TT genotype of the -790G>T polymorphism was associated with a decreased risk of HF-related death as compared with GT genotype (hazard ratio [HR] = 0.512, 95%confidence interval [CI] 0.285–0.920). However, this association was lost after adjusting for clinical covariates (HR = 0.703, 95%CI 0.365–1.353). Haplotype analysis revealed similar findings, as patients homozygous for the -1575G/-1059G/-790T haplotype had a lower rate of HF-related death than those with any other haplotype combination (12.9% versus 28.5%, respectively; P = 0.010). Again, this association did not remain after adjusting for clinical covariates (HR = 0.521, 95%CI 0.248–1.093). Our study does not exclude the possibility that polymorphisms inMMP-2 gene, particularly the -790G>T polymorphism, might be related to HF prognosis. However, due to the limitations of the study, our findings need to be confirmed in further larger studies.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofPLoS ONE. San Francisco. Vol. 11, no. 8 (Aug. 2016), e0161666, 15 p.pt_BR
dc.rightsOpen Accessen
dc.subjectBiomarcadorespt_BR
dc.subjectInsuficiência cardíacapt_BR
dc.subjectPredisposição genética para doençapt_BR
dc.subjectFatores de riscopt_BR
dc.subjectComorbidadept_BR
dc.subjectPolimorfismo de nucleotídeo únicopt_BR
dc.titleMatrix metalloproteinase-2 polymorphisms in chronic heart failure : relationship with susceptibility and long-term survivalpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001072981pt_BR
dc.type.originEstrangeiropt_BR


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