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dc.contributor.authorFarinon, Mirianpt_BR
dc.contributor.authorLora, Priscila Schmidtpt_BR
dc.contributor.authorFrancescato, Leandro Nicolodipt_BR
dc.contributor.authorBassani, Valquiria Linckpt_BR
dc.contributor.authorHenriques, Amelia Teresinhapt_BR
dc.contributor.authorXavier, Ricardo Machadopt_BR
dc.contributor.authorOliveira, Patricia Gnieslaw dept_BR
dc.date.accessioned2018-07-31T02:33:17Zpt_BR
dc.date.issued2013pt_BR
dc.identifier.issn1874-3129pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/180802pt_BR
dc.description.abstractEquisetum giganteum is a plant used in traditional medicine as diuretic. From our knowledge this is the first time this plant is tested in an in vivo model of acute inflammation. To evaluate the effect of aqueous extract of giant horsetail (AEGH) as immunomodulatory therapy, antigen-induced arthritis (AIA) was generated in mice with methylated bovine serum albumin (mBSA). Inflammation was evaluated by articular nociception, leukocytes migration and lymphocyte proliferation. AEGH reduced nociception at 3, 6 and 24 h (P < 0.01), decreased leukocyte migration (P < 0.015), and inhibited lymphocyte proliferation stimulated with Concanavalin A and Lipopolysaccharide (P < 0.05). In conclusion, AEGH has an anti-inflammatory potential in acute model of inflammation, as well as immunomodulatory effect on both B and T lymphocytes, with an action independent of cytotoxicity.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofThe open rheumatology journal. Hilversum. Vol. 7, (2013), p. 129-133pt_BR
dc.rightsOpen Accessen
dc.subjectEquisetum giganteumpt_BR
dc.subjectEquisetum giganteum L.en
dc.subjectAqueous extract of giant horsetail (AEGH)en
dc.subjectImunomodulacaopt_BR
dc.subjectAntigen-induced arthritis (AIA)en
dc.subjectArtritept_BR
dc.subjectAtividade anti-inflamatóriapt_BR
dc.subjectImmunomodulatory therapyen
dc.titleEffect of aqueous extract of giant horsetail (equisetum giganteum l.) in antigen-induced arthritispt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000913229pt_BR
dc.type.originEstrangeiropt_BR


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