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A naturalistic study of high-dose unilateral ECT among severely depressed inpatients : how does it work in the clinical practice?
dc.contributor.author | Alves, Lucas Primo de Carvalho | pt_BR |
dc.contributor.author | Freire, Thiago Fernando Vasconcelos | pt_BR |
dc.contributor.author | Fleck, Marcelo Pio de Almeida | pt_BR |
dc.contributor.author | Rocha, Neusa Sica da | pt_BR |
dc.date.accessioned | 2018-07-10T02:33:20Z | pt_BR |
dc.date.issued | 2016 | pt_BR |
dc.identifier.issn | 1471-244X | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/180309 | pt_BR |
dc.description.abstract | Background: Naturalistic studies can be useful tools to understand how an intervention works in the real clinical practice. This study aims to investigate the outcomes in a naturalistically treated depressed inpatients cohort, who were referred, or not, to unilateral ECT. Methods: Depressed adults according to MINI admitted in a psychiatric unit were divided in unilateral ECT treated and non-ECT treated. Main outcomes were: depression improvement in Hamilton Rating Scale for Depression (HDRS-17) scores; response (HDRS-17 improvement ≥50 %); remission (HDRS-17 score ≤7); length of hospitalization. Results: Forty-three patients were included in unilateral ECT group and 104 in non-ECT group. No differences of psychotic symptoms, melancholic features or past maniac episode were found between groups. Unilateral ECT group had a mean HDRS-17 score higher than non-ECT group at admission (ECT: 25.05 ± 1.03; non-ECT: 21.61 ± 0.69; p = 0.001), but no significant difference was found at discharge (ECT: 7.70 ± 0.81; non-ECT: 7.40 ± 0.51; p = 0.75). Unilateral ECT group had a larger HDRS-17 score reduction during treatment (ECT: 18.24 ± 1.18; non-ECT:14.20 ± 0.76; p = 0.004). There were no significant differences in response and remission rates between groups. Unilateral ECT group had longer mean duration of hospitalization in days (ECT: 35.48 ± 2.48; non-ECT: 24.57 ± 1.50; p < 0.001), but there were no difference in mean time of treatment (ECT group:27.66 ± 1.95; non-ECT: 24.57 ± 1.50; p = 0.25). Conclusions: Unilateral high-dose ECT is still a useful treatment option, in the real world clinical practice, to reduce the intensity of depressive symptoms in highly depressed inpatients. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | BMC psychiatry. London. Vol. 16 (2016), 396, 8 p. | pt_BR |
dc.rights | Open Access | en |
dc.subject | Transtorno depressivo maior | pt_BR |
dc.subject | Electroconvulsive therapy | en |
dc.subject | Depressive disorder | en |
dc.subject | Terapia combinada | pt_BR |
dc.subject | Naturalistic study | en |
dc.subject | Eletroconvulsoterapia | pt_BR |
dc.subject | Pragmatic clinical trials as topic | en |
dc.subject | Antidepressivos | pt_BR |
dc.subject | Resultado do tratamento | pt_BR |
dc.subject | Tempo de internação | pt_BR |
dc.title | A naturalistic study of high-dose unilateral ECT among severely depressed inpatients : how does it work in the clinical practice? | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001067369 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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