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dc.contributor.authorRegner, Gabriela Gregorypt_BR
dc.contributor.authorPereira, Patriciapt_BR
dc.contributor.authorLeffa, Douglas Teixeirapt_BR
dc.contributor.authorOliveira, Carla dept_BR
dc.contributor.authorVercelino, Rafaelpt_BR
dc.contributor.authorFregni, Felipept_BR
dc.contributor.authorTorres, Iraci Lucena da Silvapt_BR
dc.date.accessioned2018-06-15T02:48:13Zpt_BR
dc.date.issued2018pt_BR
dc.identifier.issn1662-5161pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/179385pt_BR
dc.description.abstractEpilepsy is a chronic brain syndrome characterized by recurrent seizures resulting from excessive neuronal discharges. Despite the development of various new antiepileptic drugs, many patients are refractory to treatment and report side effects. Non-invasive methods of brain stimulation, such as transcranial direct current stimulation (tDCS), have been tested as alternative approaches to directly modulate the excitability of epileptogenic neural circuits. Although some pilot and initial clinical studies have shown positive results, there is still uncertainty regarding the next steps of investigation in this field. Therefore, we reviewed preclinical and clinical studies using the following framework: (1) preclinical studies that have been successfully translated to clinical studies, (2) preclinical studies that have failed to be translated to clinical studies, and (3) clinical findings that were not previously tested in preclinical studies. We searched PubMed, Web of Science, Embase, and SciELO (2002–2017) using the keywords “tDCS,” “epilepsy,” “clinical trials,” and “animal models.” Our initial search resulted in 64 articles. After applying inclusion and exclusion criteria, we screened 17 full-text articles to extract findings about the efficacy of tDCS, with respect to the therapeutic framework used and the resulting reduction in seizures and epileptiform patterns. We found that few preclinical findings have been translated into clinical research (number of sessions and effects on seizure frequency) and that most findings have not been tested clinically (effects of tDCS on status epilepticus and absence epilepsy, neuroprotective effects in the hippocampus, and combined use with specific medications). Finally, considering that clinical studies on tDCS have been conducted for several epileptic syndromes, most were not previously tested in preclinical studies (Rasmussen’s encephalitis, drug resistant epilepsy, and hippocampal sclerosis-induced epilepsy). Overall, most studies report positive findings. However, it is important to underscore that a successful preclinical study may not indicate success in a clinical study, considering the differences highlighted herein. Although most studies report significant findings, there are still important insights from preclinical work that must be tested clinically. Understanding these factors may improve the evidence for the potential use of this technique as a clinical tool in the treatment of epilepsy.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofFrontiers in human neuroscience. Lousanne. Vol. 12 (Mar. 2018), article 189, 13 p.pt_BR
dc.rightsOpen Accessen
dc.subjectEpilepsiapt_BR
dc.subjectAnimal modelsen
dc.subjectEstimulação transcraniana por corrente contínuapt_BR
dc.subjectClinical trialsen
dc.subjectRevisãopt_BR
dc.subjectEpilepsyen
dc.subjectNon-invasive brain stimulationen
dc.subjectTranscranial direct current stimulationen
dc.titlePreclinical to clinical translation of studies of transcranial direct-current stimulation in the treatment of epilepsy : a systematic reviewpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001065424pt_BR
dc.type.originEstrangeiropt_BR


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